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4-氨基-3-羟基丁酸

4-氨基-3-羟基丁酸用途

有机合成。医药上用作抗惊厥药。

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4-氨基-3-羟基丁酸名称

[ CAS 号 ]:
924-49-2

[ 中文名 ]:
4-氨基-3-羟基丁酸

[ 英文名 ]:
DL-γ-Amino-β-hydroxybutyric acid

[中文别名 ]:

[英文别名 ]:

3-Hydroxy-4-aminobutyric acid
γ-amino-β-hydroxybutyric acid
3-hydroxy-4-amino-butyric acid (GABOB)
3-hydroxy-GABA
β-Hydroxy-GABA
3-hydroxy-4-amino-butyric acid
Butanoic acid, 4-amino-3-hydroxy-
β-Hydroxy-γ-aminobutyric acid
4-Amino-3-hydroxybutanoic acid
g-Amino-b-hydroxybutyric Acid

4-氨基-3-羟基丁酸生物活性

[ 描述 ]:

Gamibetal是γ-氨基-β-羟基丁酸。Gamibetal具有研究癫痫的潜力[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Grbesa B, et al. Gamibetal (gama-amino-beta-hidroksibuterna kiselina--GABOB) u lecenju epilepsije [Gamibetal (gamma-amino-beta-hydroxybutyric acid--GABOB) in the treatment of epilepsy]. Med Glas. 1967;21(3):75-77.

4-氨基-3-羟基丁酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
374.5±32.0 °C at 760 mmHg

[ 熔点 ]:
223ºC (dec.)(lit.)

[ 分子式 ]:
C₄H₉NO₃

[ 分子量 ]:
119.119

[ 闪点 ]:
180.3±25.1 °C

[ 精确质量 ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.73

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.511

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
almost transparency

4-氨基-3-羟基丁酸MSDS

4-氨基-3-羟基丁酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
ES7015000

[ 海关编码 ]:
2922509090

4-氨基-3-羟基丁酸合成路线

4-氨基-3-羟基丁酸上下游产品

4-氨基-3-羟基丁酸上游产品

4-氨基-3-羟基丁酸下游产品

4-氨基-3-羟基丁酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-氨基-3-羟基丁酸文献

Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.

Bioorg. Med. Chem. Lett. 18 , 402-4, (2008)

The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonis...

GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.

J. Med. Chem. 28(11) , 1612-7, (1985)

(RS)-5-(Aminomethyl)-2-isoxazolin-3-ol (dihydromuscimol, DHM) is a potent 4-aminobutyric acid (GABA) agonist, the inhibitory effects of which on neurons are sensitive to the antagonist bicuculline met...

Formation of gamma-amino-beta-hydroxybutyric acid from 2-hydroxyputrescine in rat brain.

J. Neurochem. 51(2) , 548-51, (1988)

gamma-Amino-beta-[3H]hydroxybutyric acid ([3H]-GABOB) was formed in rat brain from 2-[3H]-hydroxyputrescine that had been chemically synthesized from 2-oxoputrescine and [3H]sodium borohydride. After ...

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