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N,N'-二(2-萘基)对苯二胺

N,N'-二(2-萘基)对苯二胺用途

二芬NN是一种抗氧化剂。二芬NN诱导小鼠白细胞增多症和局部肉瘤[1][2]。。

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N,N'-二(2-萘基)对苯二胺名称

[ CAS 号 ]:
93-46-9

[ 中文名 ]:
N,N'-二-2-萘基-1,4-苯二胺

[ 英文名 ]:
N,N'-Di(2-naphthyl)-1,4-benzenediamine

[中文别名 ]:

[英文别名 ]:

1,4-Benzenediamine, N,N-di-2-naphthalenyl-
N,N'-Di-naphthalen-2-yl-benzene-1,4-diamine
MFCD00053487
EINECS 202-249-2
N,N'-Di(2-naphthyl)benzene-1,4-diamine
1-N,4-N-dinaphthalen-2-ylbenzene-1,4-diamine
N,N'-Di(2-naphthyl)-1,4-benzenediamine

N,N'-二(2-萘基)对苯二胺生物活性

[ 描述 ]:

二芬NN是一种抗氧化剂。二芬NN诱导小鼠白细胞增多症和局部肉瘤[1][2]。。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体内研究]

二芬NN(40毫克/小鼠；皮下注射；每周一次,贯穿一生) 诱导小鼠白血病和局部肉瘤[1]

[参考文献]

[1]. Pylev LN, et al. Carcinogenicity of diafen NN. Voprosy Onkologii (1977), 23(12), 75-7.

[2]. Mukhutdinov E A, et al. Quantum-Chemical Modelling and Prediction of the Structure and Functional Activity of Free Radicals and Biradicals of N-Phenyl-N′-Isopropyl-P-Phenylenediamine and N, N′-Diphenyl-P-Phenylenediamine[J]. International Polymer Science and Technology, 2009, 36(7): 13-17.

N,N'-二(2-萘基)对苯二胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
608.1±35.0 °C at 760 mmHg

[ 熔点 ]:
225-229°C

[ 分子式 ]:
C₂₆H₂₀N₂

[ 分子量 ]:
360.45

[ 闪点 ]:
399.0±17.7 °C

[ 精确质量 ]:
360.162659

[ PSA ]:
24.06000

[ LogP ]:
5.78

[ 外观性状 ]:
淡灰色白色粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.772

[ 储存条件 ]:
室温

[ 水溶解性 ]:
<0.1 g/100 mL at 19 ºC

N,N'-二(2-萘基)对苯二胺MSDS

详细MSDS(安全技术说明书)

N,N'-二(2-萘基)对苯二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ST2100000

CHEMICAL NAME :: p-Phenylenediamine, N,N'-(di-2-naphthyl)-

CAS REGISTRY NUMBER :: 93-46-9

BEILSTEIN REFERENCE NO. :: 2224419

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C26-H20-N2

MOLECULAR WEIGHT :: 360.48

WISWESSER LINE NOTATION :: L66J CMR DM- CL66J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 500 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84527 No. of Facilities: 58 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 1677 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84527 No. of Facilities: 216 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 9999 (estimated) No. of Female Employees: 2908 (estimated)

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N,N'-二(2-萘基)对苯二胺安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S36/37/39

[ RTECS号 ]:
ST2100000

[ 海关编码 ]:
2921590090

N,N'-二(2-萘基)对苯二胺合成路线

详细合成路线

N,N'-二(2-萘基)对苯二胺上下游产品

N,N'-二(2-萘基)对苯二胺上游产品

N,N'-二(2-萘基)对苯二胺下游产品

N,N'-二(2-萘基)对苯二胺制备

由对苯二胺与β-萘酚缩合而得。将对苯二胺和β-萘酚加入高压釜中，于260-265℃进行缩合反应。反应结束后，将反应产物加入酒精中回流，冷却，过滤，再用乙醇洗涤，干燥，粉碎即得成品。

也可以采用催化缩合法，降低对苯二胺与2-萘酚的投料比，反应效率提高。

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N,N'-二(2-萘基)对苯二胺海关

[ 海关编码 ]: 2921590090

[ 中文概述 ]:
2921590090. 其他芳香多胺及衍生物及它们的盐. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N,N'-二(2-萘基)对苯二胺

N,N'-二(2-萘基)对苯二胺用途

N,N'-二(2-萘基)对苯二胺名称

N,N'-二(2-萘基)对苯二胺生物活性

N,N'-二(2-萘基)对苯二胺物理化学性质

N,N'-二(2-萘基)对苯二胺MSDS

详细MSDS(安全技术说明书)

N,N'-二(2-萘基)对苯二胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

N,N'-二(2-萘基)对苯二胺安全信息

N,N'-二(2-萘基)对苯二胺合成路线

详细合成路线

N,N'-二(2-萘基)对苯二胺上下游产品

N,N'-二(2-萘基)对苯二胺上游产品

N,N'-二(2-萘基)对苯二胺下游产品

N,N'-二(2-萘基)对苯二胺制备

N,N'-二(2-萘基)对苯二胺海关

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