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(S)-(-)-阿替洛尔

(S)-(-)-阿替洛尔名称

[ CAS 号 ]:
93379-54-5

[ 中文名 ]:
S-(-)-阿替洛尔

[ 英文名 ]:
esatenolol

[英文别名 ]:

S-(-)-Atenolol
MFCD00074918
(-)-Atenolol
1-Phenylbiguanide hydrochloride
Esatenolol [INN]
Esatenolol

(S)-(-)-阿替洛尔物理化学性质

[ 密度 ]:
1.125 g/cm3

[ 沸点 ]:
508ºC at 760mmHg

[ 熔点 ]:
148-152 ºC(lit.)

[ 分子式 ]:
C₁₄H₂₂N₂O₃

[ 分子量 ]:
266.33600

[ 闪点 ]:
261.1ºC

[ 精确质量 ]:
266.16300

[ PSA ]:
84.58000

[ LogP ]:
1.54330

[ 外观性状 ]:
淡粉红色固体

(S)-(-)-阿替洛尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1488020

CHEMICAL NAME :: Benzeneacetamide, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, (S)-

CAS REGISTRY NUMBER :: 93379-54-5

LAST UPDATED :: 199403

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H22-N2-O3

MOLECULAR WEIGHT :: 266.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 97 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PIXXD2 PCT (Patent Cooperation Treaty) International Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #91-10428

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(S)-(-)-阿替洛尔安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CY1488020

[ 海关编码 ]:
2924299090

(S)-(-)-阿替洛尔合成路线

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(S)-(-)-阿替洛尔海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(S)-(-)-阿替洛尔文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Effects of nebivolol on endothelial gene expression during oxidative stress in human umbilical vein endothelial cells.

Mediators Inflamm. 2008 , 367590, (2008)

The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare th...

The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol on the rat left atria and portal vein.

Chirality 5 , 8-14, (1993)

The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol alone on the rat left atria and portal vein and on the respective beta 1- and beta 2-adrenoceptor-mediated responses to isoprenal...

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