邻苯二胺(OPD)
邻苯二胺(OPD)用途
邻苯二胺(OPD)名称
[ CAS 号 ]:
95-54-5
[ 中文名 ]:
1,2-苯二胺
[ 英文名 ]:
o-Phenylenediamine
[中文别名 ]:
[英文别名 ]:
- 1,2-diaminobenzene
- OPD
- 1,2-Benzenediamine
- Benzol-1,2-diamin
- diaminobenzene
- benzene-1,2-diamine
- ortho-phenylenediamine
- EINECS 202-430-6
- o-phenylenediamine
- 1,2-Phenylene diamine
邻苯二胺(OPD)物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
257.0±0.0 °C at 760 mmHg
[ 熔点 ]:
99-102 °C
[ 分子式 ]:
C6H8N2
[ 分子量 ]:
108.141
[ 闪点 ]:
124.9±19.3 °C
[ 精确质量 ]:
108.068748
[ PSA ]:
52.04000
[ LogP ]:
0.05
[ 外观性状 ]:
棕色黄色,红色棕色或棕色晶体
[ 蒸汽密度 ]:
3.7 (vs air)
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.661
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
[ 水溶解性 ]:
H2O: 1 tablet/10 mL, clear, colorless
邻苯二胺(OPD)MSDS
邻苯二胺(OPD)毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SS7875000
- CHEMICAL NAME :
- o-Phenylenediamine
- CAS REGISTRY NUMBER :
- 95-54-5
- BEILSTEIN REFERENCE NO. :
- 0606074
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 36
- MOLECULAR FORMULA :
- C6-H8-N2
- MOLECULAR WEIGHT :
- 108.16
- WISWESSER LINE NOTATION :
- ZR BZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 510 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1873 mg/m3
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 516 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 660 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 366 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >91 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 336 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 360 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 360 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 133 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- DNA inhibition
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TEST SYSTEM :
- Rodent - guinea pig
- DOSE/DURATION :
- 216 mg/kg/24H
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 43,249,1980 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.1 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4334 No. of Facilities: 342 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 3076 (estimated) No. of Female Employees: 1372 (estimated)
邻苯二胺(OPD)安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H312 + H332-H317-H319-H341-H351-H410
[ 警示性声明 ]:
Missing Phrase - N15.00950417-P261-P280-P305 + P351 + P338
[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R20/21;R36;R40;R43;R50/53;R68
[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S1/2
[ 危险品运输编码 ]:
UN 1673 6.1/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
SS7875000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29215119
邻苯二胺(OPD)合成路线
邻苯二胺(OPD)上下游产品
邻苯二胺(OPD)上游产品
邻苯二胺(OPD)下游产品
邻苯二胺(OPD)制备
1、以邻硝基苯胺为原料，用硫化钠还原法或催化加氢还原法制得邻苯二胺。在还原锅内加入21%的硫化钠溶液和邻硝基苯胺，升温至90℃，密闭升温至105-110℃，压力自升为0.1-0.2MPa，搅拌还原5h，降温至40℃以下，过滤。将滤饼加热熔化，减压蒸馏，收集140-210℃（7.89kPa）馏分即为邻苯二胺，收率70-80%。加氢过程在高压釜中进行，反应温度为95-105℃，压力为2MPa左右，在镍催化剂作用下通氢反应约1h，至氢压不下降为止。邻苯二胺的收率在97%以上。
2、其制备方法有以下几种。
邻硝基苯胺与硫化钠还原法
用邻硝基苯胺与硫化钠溶液在压力98～196kPa、反应温度105～110℃情况下反应，亦可在反应温度120～130℃和常压下进行，反应时间3～4h，得到邻苯二胺。
邻硝基苯胺加氢还原法
以邻硝基苯胺为原料，兰尼镍为催化剂，在高压釜中控制温度95～105℃，连续通氢气至压力不降为止，在1.960 MPa压力下搅拌反应得到产品。
上述两个制备方法中，用硫化钠还原法得到产品的纯度较高，工艺路线比较成熟，国内有较多的工厂用此法生产邻苯二胺。但该方法劳动保护条件较差，废水较多。而催化加氢法在工艺上还存在些问题，工业化有待进一步改进。此外还有邻二氯苯氨解法，国内有较多单位曾进行研究，但尚未工业化。
3、在装有液封机械搅拌器及回流冷凝器的1升三颈回底烧瓶中，放入69克(0.5摩尔)邻硝基苯胺、40毫升20氢氧化钠溶液及200毫升95%乙醇。将混合物剧烈搅拌并在蒸汽浴上加热至溶液缓缓沸腾。停止加热，把130克(2克原子)针粉(纯度不低于80%,用量按130克纯度100%的物质计算)分成每份10克逐次加入，间隔的时间J以保持溶液沸腾为度。加完锌粉后，将混合物回并继续搅拌1小时，溶液的颜色从深红变为近于无色。把热混合物进行吸滤，并将残留的锌放回烧瓶中，用每份I}}毫升的热乙醇提取二次。加2一3克亚硫酸氢钠至合并后的滤液中，然后把溶液在减压下(用水泵)于蒸汽浴上浓缩至体积为125-150毫升。在冰盐浴中充分冷却后，收集淡黄色晶体，用少量冰水洗一次，放在真空干燥器中干燥。在}'7-1 }}融化的粗邻苯二胺的产量是46一50克(85-93%）。如果需要较纯的产品，可把产物溶解在含有1一2克亚硫酸氢钠的150-175毫升热水中，并用活性炭处理。在冰盐致冷剂中充分冷却后，滤出无色晶体并用10=15毫升冰水洗涤。
也可把游离的二胺用下法变为二盐酸盐，并精制之。把粗的邻苯二胺溶解在由90-100毫升浓盐酸(比重1.19及含有2一3克氛化亚锡的50-60毫升水所成的混合物中，将热溶液用活性炭处理。在热的无色滤液中加入150毫升浓盐酸，然后在冰一盐浴中充分冷却。吸滤出无色晶体，用少量冷的浓盐酸洗涤，于真空中在固体氢氧化钠上干燥。邻苯二胺二盐酸的产量是77一81克(根据所用邻硝基苯胺的重量计算，为理论产量的85-90%
邻苯二胺(OPD)海关
[ 海关编码 ]: 2921511000
[ 中文概述 ]:
2921511000 邻苯二胺。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:4.0%。普通关税:11.0%
[ Summary ]:
2921511000 benzene-1,2-diamine。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:4.0%。General tariff:11.0%
邻苯二胺(OPD)文献
Biochim. Biophys. Acta 1848(2) , 712-20, (2014)
The surrounding environment has significant consequences for the structural and functional properties of membrane proteins. While native structure and function can be reconstituted in lipid bilayer me...
Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.PLoS ONE 10(3) , e0119423, (2015)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In...
A method for sampling microbial aerosols using high altitude balloons.J. Microbiol. Methods 107 , 161-8, (2015)
Owing to the challenges posed to microbial aerosol sampling at high altitudes, very little is known about the abundance, diversity, and extent of microbial taxa in the Earth-atmosphere system. To dire...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥188.0/100g
联系人：刘佳
产品详情：邻苯二胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥39.0/5g
￥99.0/100g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：邻苯二胺（OPD）
公司名：山东金悦源新材料有限公司
区域：济南市天桥区
价格：
￥625.0/25kg
联系人：王思兵
产品详情：邻苯二胺
公司名：济南世纪通达化工有限公司
区域：济南市天桥区
价格：
￥38000.0/1ton
联系人：王经理
产品详情：邻苯二胺
查看所有供应商请点击：
相关化合物
【邻苯二胺(OPD)】化源网提供邻苯二胺(OPD)CAS号95-54-5，邻苯二胺(OPD)MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询邻苯二胺(OPD)上化源网，专业又轻松。>>电脑版：邻苯二胺(OPD)
标题：邻苯二胺(OPD)_MSDS_用途_密度_CAS号【95-54-5】_化源网 地址：https://m.chemsrc.com/mip/cas/95-54-5_950966.html