乳酸乙酯
乳酸乙酯用途
用作硝化纤维和乙酸纤维的溶剂，也用于香料工业
【用途二】
乳酸乙酯是我国规定允许使用的食用香料，常用于调制果香型、乳酸型食用和酒用香精。用量按正常生产需要，一般在酒类饮料中1000mg/kg、口香糖中580-3100 mg/kg、烘烤食品中71 mg/kg、糖果中28 mg/kg、冷饮中17 mg/kg。
【用途三】
GB 2760—96规定为允许使用的食用香料。载体溶剂。作为香料主要用于配制朗姆酒、牛奶、奶油、葡萄、果酒、椰子等型香精。
【用途四】
硝化纤维及乙酸纤维溶剂。有机合成。食品添加剂。
乳酸乙酯名称
[ CAS 号 ]:
97-64-3
[ 中文名 ]:
乳酸乙酯
[ 英文名 ]:
Ethyl lactate
[中文别名 ]:
[英文别名 ]:
- (±)-Ethyl 2-hydroxypropionate
- QY1&VO2
- (±)-Ethyl lactate
- Actylol
- (±)-Ethyl 2-hydroxypropanoate
- Purasolv ELS
- FEMA 2440
- 2-Hydroxypropanoic acid ethyl ester
- Ethyl 2-hydroxypropanoate
- lactic acid ethyl ester
乳酸乙酯物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
154.5±0.0 °C at 760 mmHg
[ 熔点 ]:
-26°C
[ 分子式 ]:
C5H10O3
[ 分子量 ]:
118.131
[ 闪点 ]:
48.9±0.0 °C
[ 精确质量 ]:
118.062996
[ PSA ]:
46.53000
[ LogP ]:
-0.19
[ 外观性状 ]:
无色液体
[ 蒸汽压 ]:
1.2±0.6 mmHg at 25°C
[ 折射率 ]:
1.420
[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
水溶性：完全混溶；混溶：氯仿,乙醚,醇
乳酸乙酯MSDS
乳酸乙酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OD5075000
- CHEMICAL NAME :
- Lactic acid, ethyl ester
- CAS REGISTRY NUMBER :
- 97-64-3
- BEILSTEIN REFERENCE NO. :
- 1209448
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C5-H10-O3
- MOLECULAR WEIGHT :
- 118.15
- WISWESSER LINE NOTATION :
- QVY1&O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,677,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 11,150,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 65,89,1939
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 65,89,1939
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 65,89,1939
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,677,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2605 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,189,1942 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1136 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1136 No. of Facilities: 298 (estimated) No. of Industries: 5 No. of Occupations: 23 No. of Employees: 7298 (estimated) No. of Female Employees: 1962 (estimated)
乳酸乙酯安全信息
[ 符号 ]:
GHS02, GHS05, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H226-H318-H335
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi:Irritant
[ 风险声明 (欧洲) ]:
R10;R37;R41
[ 安全声明 (欧洲) ]:
S24-S26-S39
[ 危险品运输编码 ]:
1192
[ RTECS号 ]:
OD5075000
[ 包装等级 ]:
III
[ 危险类别 ]:
3.2
[ 海关编码 ]:
2918110000
乳酸乙酯合成路线
乳酸乙酯上下游产品
乳酸乙酯上游产品
乳酸乙酯下游产品
乳酸乙酯制备
1.金属卤物催化法。用金属卤化物代替浓硫酸催化合成乳酸乙酯，收率65%-71%。
2.稀土化合物催化法。将乙醇0.22-0.33mol、乳酸0.11mol，带水剂25mL和稀土化合物（与酸的摩尔比为1：100）加入烧瓶，回流反应2.5-3h，反应液蒸去过量的乙醇、带水剂和未反应的乳酸后减压蒸馏，收集产品，产率74%-79%。
3.硫酸催化法。在硫酸催化下乳酸与过量的乙醇酯化而得乳酸乙酯；也可在四氯化碳中加热会流脱水24h，常压蒸馏回收过量的乙醇，再减压蒸馏出成品。
4.固体酸催化法。NaY分子筛经水洗，干燥、高温灼烧，再用一定浓度NH4Cl溶液搅拌浸渍，进行离子交换，将NH4Y过滤、洗涤、干燥，550℃高温活化，即得固体酸HY。然后将乳酸、乙醇、苯、HY加入反应瓶，HY/乳酸（质量比）=25/100，乳酸/乙醇（摩尔比）=1/3。在100-160℃下回流分水反应8-10h，酯化率60%以上。
5.蒸馏酯化法。将225g80%的乳酸、475Ml(380g)95%的乙醇、100mL苯、2 mL浓硫酸和少许沸石加入分水蒸馏装置的烧瓶（1000 mL）中。加入反应液至沸，蒸汽（乙醇、苯和水）经蒸馏柱后进入冷凝器，分出水层后回流至蒸馏柱，柱顶温度稳定在64.9℃。当分出水层240g（其中含乙醇119g、水99g、苯22g）后，基本无水分出，柱顶温度升至68℃时，酯化结束。反应液冷却后加入6g无水醋酸钠中和硫酸，进行减压蒸馏。先全回流1h，然后在2.45Kpa的真空度下，控制回流比不小于5，柱顶温度58℃，蒸馏无色清亮的乳酸乙酯226g，收率96%。
6.由乳酸与过量的乙醇在催化剂作用下酯化，经精制而得。
乳酸乙酯海关
[ 海关编码 ]: 2918110000
[ 中文概述 ]:
2918110000. 乳酸及其盐和酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
[ Summary ]:
2918110000. lactic acid, its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
乳酸乙酯文献
Appl. Microbiol. Biotechnol. 99(5) , 2291-304, (2015)
Volatile compounds produced by yeast during fermentation greatly influence the organoleptic qualities of wine. We developed a model to predict the combined effects of initial nitrogen and phytosterol ...
Use of ethyl lactate to extract bioactive compounds from Cytisus scoparius: Comparison of pressurized liquid extraction and medium scale ambient temperature systems.Talanta 140 , 134-42, (2015)
An important trend in the extraction of chemical compounds is the application of new environmentally friendly, food grade solvents. Ethyl lactate (ethyl 2-hydroxypropanoate), produced by fermentation ...
Mosquito odorant receptor for DEET and methyl jasmonate.Proc. Natl. Acad. Sci. U. S. A. 111(46) , 16592-7, (2014)
Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbe...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：乳酸乙酯
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥138.0/500ml
联系人：刘佳
产品详情：乳酸乙酯
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1mg
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：乳酸乙酯
公司名：中山市迪欣化工有限公司
区域：中山市三角镇
价格：
￥45.0/100kg
联系人：陈雪萍
产品详情：乳酸乙酯
查看所有供应商请点击：
相关化合物
【乳酸乙酯】化源网提供乳酸乙酯CAS号97-64-3，乳酸乙酯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询乳酸乙酯上化源网，专业又轻松。>>电脑版：乳酸乙酯
标题：乳酸乙酯_MSDS_用途_密度_乳酸乙酯CAS号【97-64-3】_化源网 地址：https://m.chemsrc.com/mip/cas/97-64-3_161999.html