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氨基甲酸乙酯

氨基甲酸乙酯用途

Urethane已被用作抗肿瘤剂和其他医药用途。

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氨基甲酸乙酯名称

[ CAS 号 ]:
51-79-6

[ 中文名 ]:
氨基甲酸乙酯

[ 英文名 ]:
Urethane

[中文别名 ]:

[英文别名 ]:

Ethyl urethane
urethane
Ethyl Carbamate
caproic acid ethyl ester
Carbamic Acid Ethyl Ester
Capronic ether absolute
2-Ethyl Hexanoate
ethyl carbaminate
ethyl n-heptanoate
Carbamate, Ethyl

氨基甲酸乙酯生物活性

[ 描述 ]:

Urethane已被用作抗肿瘤剂和其他医药用途。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[相关活性小分子]

氨基甲酸乙酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
105.7±23.0 °C at 760 mmHg

[ 熔点 ]:
48-50 °C(lit.)

[ 分子式 ]:
C₃H₇NO₂

[ 分子量 ]:
89.093

[ 闪点 ]:
17.7±22.6 °C

[ 精确质量 ]:
89.047676

[ PSA ]:
52.32000

[ LogP ]:
0.07

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽密度 ]:
3.07 (vs air)

[ 蒸汽压 ]:
15.9±0.4 mmHg at 25°C

[ 折射率 ]:
1.423

[ 储存条件 ]:
Room temperature.

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

[ 水溶解性 ]:
slightly soluble

氨基甲酸乙酯MSDS

详细MSDS(安全技术说明书)

氨基甲酸乙酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H350

[ 警示性声明 ]:
P201-P301 + P312 + P330-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R45

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
FA8400000

[ 海关编码 ]:
2924199090

氨基甲酸乙酯合成路线

详细合成路线

氨基甲酸乙酯上下游产品

氨基甲酸乙酯上游产品

氨基甲酸乙酯下游产品

氨基甲酸乙酯制备

硝酸与尿素反应生成硝酸尿素，然后加乙醇、亚硝酸钠，在硫酸存在下，进行酯化反应，生成尿烷和硝酸钠，反应产物经过滤除去硝酸钠，再经蒸馏、结晶、干燥，制得成品。

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氨基甲酸乙酯海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氨基甲酸乙酯文献

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis.

J. Pharmacol. Exp. Ther. 352(3) , 462-70, (2015)

Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug...

Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.

Oncogene 33(44) , 5193-200, (2014)

Presenilins are the enzymatic components of γ-secretase complex that cleaves amyloid precursor protein, Notch and β-catenin, which has critical roles in the development of Alzheimer's disease and canc...

The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.

Arch. Toxicol. 88(9) , 1695-709, (2014)

Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and ...

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