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野黑樱苷

野黑樱苷用途

Prunasin是DNA聚合酶β的抑制剂[1]。

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野黑樱苷名称

[ CAS 号 ]:
99-18-3

[ 中文名 ]:
野黑樱苷

[ 英文名 ]:
Prunasin

[英文别名 ]:

Prunasin
(2S)-(β-D-Glucopyranosyloxy)(phenyl)acetonitrile
D-Prunasin

野黑樱苷生物活性

[ 描述 ]:

Prunasin是DNA聚合酶β的抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[参考文献]

[1]. Mizushina Y, et al. The cyanogenic glucoside, prunasin (D-mandelonitrile-beta-D-glucoside), is a novel inhibitor of DNA polymerase beta. J Biochem. 1999;126(2):430-436.

野黑樱苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
527.0±50.0 °C at 760 mmHg

[ 熔点 ]:
138-148ºC

[ 分子式 ]:
C₁₄H₁₇NO₆

[ 分子量 ]:
295.29

[ 闪点 ]:
272.5±30.1 °C

[ 精确质量 ]:
295.105591

[ PSA ]:
123.17000

[ LogP ]:
-0.92

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.621

[ 储存条件 ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

野黑樱苷MSDS

野黑樱苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UL3420000

CHEMICAL NAME :: Prunasin

CAS REGISTRY NUMBER :: 99-18-3

BEILSTEIN REFERENCE NO. :: 0091509

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H17-N-O6

MOLECULAR WEIGHT :: 295.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 177 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 215,1513,1982

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野黑樱苷安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H360

[ 警示性声明 ]:
P201-P301 + P310-P308 + P313

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
UL3420000

野黑樱苷合成路线

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野黑樱苷文献

Chromatographic determination of cyanoglycosides prunasin and amygdalin in plant extracts using a porous graphitic carbon column.

J. Agric. Food Chem. 50(24) , 6960-3, (2002)

The determination of cyanogenic compounds in plants is often performed by HPLC. However, in this analysis, interferences due to compounds in the matrix, such as tannins and other pigments, are encount...

Larvae of the fall webworm, Hyphantria cunea, inhibit cyanogenesis in Prunus serotina.

J. Immunol. Methods 211 , 671-7, (2008)

The larvae of the fall webworm, Hyphantria cunea (Dru.), though vulnerable to cyanide poisoning, consume the cyanogenic leaves of black cherry, Prunus serotina, without apparent harm. The cyanide cont...

Generation of primary amide glucosides from cyanogenic glucosides

Phytochemistry 70(3) , 388-93, (2009)

The conversion of the cyanogenic glucoside prunasin into the corresponding prunasinamide has been observed in the leaves of Olinia ventosa and other prunasin-containing species only if reactive oxygen...

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