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四环素亚甲赖氨酸

四环素亚甲赖氨酸用途

Lymecycline 是四环素衍生物,具有广谱的抗菌活性,同时具有抗炎活性。

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四环素亚甲赖氨酸名称

[ CAS 号 ]:
992-21-2

[ 中文名 ]:
赖甲环素

[ 英文名 ]:
Lymecycline

[中文别名 ]:

四环素亚甲赖氨酸

[英文别名 ]:

limecycline
lycopsamine
(+)-Indicine

四环素亚甲赖氨酸生物活性

[ 描述 ]:

Lymecycline 是四环素衍生物,具有广谱的抗菌活性,同时具有抗炎活性。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Bacterial[1]

[体外研究]

利美环素是一种四环素衍生物,具有广谱抗菌活性,可干扰核糖体水平的原核蛋白合成。利美环素还具有抗炎特性[1]。

[参考文献]

[1]. Rempe S, et al. Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6.

四环素亚甲赖氨酸物理化学性质

[ 密度 ]:
1.53

[ 沸点 ]:
840.5ºC at 760 mmHg

[ 熔点 ]:
192.5°C

[ 分子式 ]:
C₂₉H₃₈N₄O₁₀

[ 分子量 ]:
602.63

[ 闪点 ]:
462.1ºC

[ 精确质量 ]:
602.25900

[ PSA ]:
242.98000

[ LogP ]:
1.02790

[ 折射率 ]:
1.693

[ 水溶解性 ]:
Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

四环素亚甲赖氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL5615000

CHEMICAL NAME :: Lysine, N(sup 6)-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxa mido)methyl)-, (+)-

CAS REGISTRY NUMBER :: 992-21-2

LAST UPDATED :: 199201

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H38-N4-O10

MOLECULAR WEIGHT :: 602.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,333,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 253 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,106,1964