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5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid

更新时间:2024-01-05 19:39:28

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式
5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式
委托求购
常用名 5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid 英文名 5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid
CAS号 103772-14-1 分子量 298.21700
密度 1.762g/cm3 沸点 512.4ºC at 760mmHg
分子式 C13H9F3N2O3 熔点 N/A
MSDS N/A 闪点 263.7ºC

 名称

英文名 5-amino-1-cyclopropyl-6,7,8-trifluoro-4-oxoquinoline-3-carboxylic acid
英文别名 更多

 物理化学性质

密度 1.762g/cm3
沸点 512.4ºC at 760mmHg
分子式 C13H9F3N2O3
分子量 298.21700
闪点 263.7ºC
精确质量 298.05700
PSA 85.32000
LogP 2.61530
蒸汽压 0mmHg at 25°C
折射率 1.68

 合成线路

~97%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

~93%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Miyamoto, Teruyuki; Matsumoto, Jun-ichi; Chiba, Katsumi; Egawa, Hiroshi; Shibamori, Koh-ichiro; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1645 - 1656

~%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Cociorva, Oana M.; Li, Bei; Nomanbhoy, Tyzoon; Li, Qiang; Nakamura, Ayako; Nakamura, Kai; Nomura, Masahiro; Okada, Kyoko; Seto, Shigeki; Yumoto, Kazuhiro; Liyanage, Marek; Zhang, Melissa C.; Aban, Arwin; Leen, Brandon; Szardenings, Anna Katrin; Rosenblum, Jonathan S.; Kozarich, John W.; Kohno, Yasushi; Shreder, Kevin R. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5948 - 5951

~%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

~%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

~%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

~%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

~%

5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid结构式

5-Amino-l-Cyclo...

103772-14-1

文献:Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

 英文别名

1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-carboxylic acid
1-cyclopropyl-5-amino-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid L
1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid
ORBIFLOXACIN
Orbax
5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
1-cyclopropyl-5,6,8-trifluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid