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[[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathi olan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphon ic acid

更新时间:2024-02-15 17:27:21

[[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathi olan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphon ic acid结构式
[[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathi olan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphon ic acid结构式
品牌特惠专场
常用名 [[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathi olan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphon ic acid 英文名 [[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathi olan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphon ic acid
CAS号 145819-92-7 分子量 487.18600
密度 2.08g/cm3 沸点 N/A
分子式 C8H13FN3O12P3S 熔点 N/A
MSDS N/A 闪点 N/A

 用途


三磷酸恩曲他滨((-)-三磷酸恩屈他滨)是恩曲他嗪(HY-17427)的磷酸化合成物。恩曲他滨是一种核苷逆转录酶抑制剂。恩曲他滨是治疗HIV和HBV感染的抗逆转录病毒药物[1][2]。

 名称

英文名 [(2R,5S)-5-(6-amino-5-fluoro-2,4-dioxo-1H-pyrimidin-3-yl)-1,3-oxathiolan-2-yl]methyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid

 生物活性

描述 三磷酸恩曲他滨((-)-三磷酸恩屈他滨)是恩曲他嗪(HY-17427)的磷酸化合成物。恩曲他滨是一种核苷逆转录酶抑制剂。恩曲他滨是治疗HIV和HBV感染的抗逆转录病毒药物[1][2]。
相关类别
参考文献

[1]. Frasca K, et al. Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short-term adherence to antiretroviral therapy. J Antimicrob Chemother. 2019 May 1;74(5):1395-1401.  

[2]. Bang LM, et al. Emtricitabine: an antiretroviral agent for HIV infection. Drugs. 2003;63(22):2413-24; discussion 2425-6.  

 物理化学性质

密度 2.08g/cm3
分子式 C8H13FN3O12P3S
分子量 487.18600
精确质量 486.94200
PSA 295.69000
LogP 0.25120
折射率 1.651