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刃天青

刃天青用途

Resazurin sodium salt 经常用于通过被还原成荧光产物试卤灵来测量细菌和真核细胞活力。

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刃天青名称

[ CAS 号 ]:
62758-13-8

[ 中文名 ]:
刃天青钠

[ 英文名 ]:
Resazurin sodium salt

[中文别名 ]:

[英文别名 ]:

7-hydroxy-10-oxy-phenoxazin-3-one,sodium-compound
ResazurinGr
EINECS 263-718-5
7-sodiooxy-3H-phenoxazin-3-one 10-oxide
DIAZORESORCINOL
RESAZURIN SODIUM
7-hydroxy-3H-phenoxazin-3-one 10-oxide sodium salt
Sodium 3-oxo-3H-phenoxazin-7-olate 10-oxide
Resazurine
RESAZOIN

刃天青生物活性

[ 描述 ]:

Resazurin sodium salt 经常用于通过被还原成荧光产物试卤灵来测量细菌和真核细胞活力。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

生化试剂

研究领域 >> 其他

[体外研究]

刃天青钠盐通常用于通过将其还原为荧光产物试卤灵来测量细菌和真核细胞的活力。在土霉素LV的TSBc培养物中以44μM的浓度包含刃天青钠盐后,在接种后24小时未检测到活细菌。与单独的生长培养基相比,将刃天青钠盐浓度降低至4.4μM仍导致存活的土拉弗朗西斯菌LVS降低10倍。刃天青钠盐处理均在22小时内导致活的F. tularensis LVS细菌显着减少。用刃天青钠盐处理可显着降低感染后22小时HEK293细胞中存活的F. tularensis LVS细菌数量[1]。

[细胞实验]

F. tularensis在补充有44μM刃天青钠盐的TSBc中于37℃培养24小时。在选定的时间点，使用Spectronic 200分光光度计测量600nm和570nm处的吸光度，分别检测刃天青钠盐和试卤灵的存在。这两种光密度的比例用于评估刃天青钠盐随时间的减少对试卤灵的影响[1]。

[参考文献]

[1]. Schmitt DM, et al. The use of resazurin as a novel antimicrobial agent against Francisella tularensis. Front Cell Infect Microbiol. 2013 Dec 6;3:93.

[相关活性小分子]

刃天青物理化学性质

[ 沸点 ]:
477.2ºC at 760 mmHg

[ 熔点 ]:
>200ºC

[ 分子式 ]:
C₁₂H₆NNaO₄

[ 分子量 ]:
251.170

[ 闪点 ]:
242.4ºC

[ 精确质量 ]:
251.019455

[ PSA ]:
78.73000

[ LogP ]:
2.47010

[ 外观性状 ]:
暗红色晶体带有一种绿色光泽

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
soluble

刃天青MSDS

详细MSDS(安全技术说明书)

刃天青安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

刃天青海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

刃天青文献

Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds.

PLoS ONE 9(5) , e96348, (2014)

The tendency for mycobacteria to aggregate poses a challenge for their use in microplate based assays. Good dispersions have been difficult to achieve in high-throughput screening (HTS) assays used in...

Evaluating the anticancer properties of liposomal copper in a nude xenograft mouse model of human prostate cancer: formulation, in vitro, in vivo, histology and tissue distribution studies.

Pharm. Res. 31(11) , 3106-19, (2014)

Although Cu complexes have been investigated as anticancer agents, there has been no description of Cu itself as a cancer killing agent. A stealth liposomal Cu formulation (LpCu) was studied in vitro ...

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance.

Mol. Cell. Endocrinol. 414 , 19-28, (2015)

Adipose tissue secretes adipokines that regulate insulin sensitivity in adipocytes and other peripheral tissues critical to glucose metabolism. Insulin resistance is associated with severe alterations...

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刃天青