阿那曲唑结构式
|
常用名 | 阿那曲唑 | 英文名 | Anastrozole |
|---|---|---|---|---|
| CAS号 | 120511-73-1 | 分子量 | 293.366 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 469.7±55.0 °C at 760 mmHg | |
| 分子式 | C17H19N5 | 熔点 | 81-82°C | |
| MSDS | 中文版 美版 | 闪点 | 237.9±31.5 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
|
Changes in bone mineral density at 3 years in postmenopausal women receiving anastrozole and risedronate in the IBIS-II bone substudy: an international, double-blind, randomised, placebo-controlled trial.
Lancet Oncol. 15(13) , 1460-8, (2014) Aromatase inhibitors prevent breast cancer in postmenopausal women at high risk of the disease but are associated with accelerated bone loss. We assessed effectiveness of oral risedronate for prevention of reduction in bone mineral density (BMD) after 3 years... |
|
|
NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions.
Cancer Res. 74(16) , 4446-57, (2014) Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and activity in adipose-infiltrating macrophages. The product of this enzyme, the proinflammatory eicosanoid ... |
|
|
Impact of BMI on serum estradiol and bone turnover markers in postmenopausal women with hormone-sensitive early breast cancer treated with anastrozole.
J. Cancer Res. Clin. Oncol. 140(1) , 159-66, (2014) Obesity increases the risk of all-cause and breast cancer mortality. As obese patients have higher levels of aromatase enzyme activity, conflicting results on the effect of body mass index (BMI) of a standard dose aromatase inhibitor on estradiol depletion ha... |
|
|
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Int. J. Oncol. 46(4) , 1481-90, (2015) Aromatase inhibitor (AI) treatment is first-line systemic treatment for the majority of postmenopausal breast cancer patients with estrogen receptor (ER)-positive primary tumor. Although many patients benefit from treatment, some will develop resistance, and ... |
|
|
Sex-dependent influence of endogenous estrogen in pulmonary hypertension.
Am. J. Respir. Crit. Care Med. 190(4) , 456-67, (2014) The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against pulmonary hypertension (PH). However, in mo... |
|
|
Antiproliferative effects of anastrozole on MCF-7 human breast cancer cells in vitro are significantly enhanced by combined treatment with testosterone undecanoate.
Mol. Med. Report. 12 , 769-75, (2015) The present study aimed to assess the effects of aromatase inhibitor anastrozole and testosterone undecanoate, separately and in combination, on proliferation and apoptosis in MCF-7 human breast cancer cells cultured in vitro. The effects of various concentra... |
|
|
Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression.
Neurotoxicology 46 , 25-34, (2015) Activation of microglia may facilitate age-related impairment in cognitive functions including hippocampal-dependent memory. Considerable evidence indicates that hippocampal-derived estrogen improves hippocampal-dependent learning and memory. We hypothesize t... |
|
|
Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: long term results of the Italian Tamoxifen Anastrozole trial.
Eur. J. Cancer 49(7) , 1546-54, (2013) The Italian Tamoxifen Anastrozole (ITA) trial investigated the efficacy of switching to anastrozole for women who were already on adjuvant tamoxifen since 2-3years. Relapse-free survival (RFS) was the primary end-point; event-free survival (EFS), overall surv... |
|
|
Development and validation of a simple and sensitive high performance liquid chromatographic method for the simultaneous determination of anastrozole, bicalutamide, tamoxifen, and their synthetic impurities
Talanta 101 , 495-503, (2012) A simple and sensitive analytical method for simultaneous determination of anastrozole, bicalutamide, and tamoxifen as well as their synthetic impurities, anastrozole pentamethyl, bicalutamide 3-fluoro-isomer, and tamoxifen e-isomer, was developed and validat... |
|
|
Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor.
Fertil. Steril. 100(4) , 970-4, (2013) To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT).Case series.Academic medical center.Ten patients with Klinefelter syndrome, aged 14-22 years, treated with testosterone replacement ... |