3-硝基丙酸

PLoS ONE 9(11) , e112130, (2014)

To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear. Mitochondrial chaperones regulate mitochondrial function and structure. Chaperon...

Food Chem. 175 , 543-8, (2015)

A high performance liquid chromatography (HPLC) method was developed to assay nitropropanoyl glucosides in the nuts of karaka (Corynocarpus laevigatus) a traditional food of New Zealand Māori. Levels of glucosides, measured as 3-nitropropanoic acid, ranged fr...

Neuroscience 227 , 134-43, (2012)

Nuclear factor-erythroid 2-related factor-2 (Nrf2) mediated regulation of cellular antioxidant production and the anti-inflammatory mechanism play an important role in neuroprotection against neurodegenerative diseases. Naringin a citrus flavonone, has been r...

Neurobiol. Aging 34(11) , 2548-50, (2013)

Loss-of-function mutations in the progranulin (GRN) gene are a common cause of autosomal dominant frontotemporal lobar degeneration, a fatal and progressive neurodegenerative disorder common in people less than 65 years of age. In the brain, progranulin is ex...

Cell Death Dis. 6 , e1691, (2015)

Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell...

Biochim. Biophys. Acta 1847(4-5) , 418-28, (2015)

Spinocerebellar ataxia type 7 (SCA7) is one of the nine neurodegenerative disorders caused by expanded polyglutamine (polyQ) domains. Common pathogenic mechanisms, including bioenergetics defects, have been suggested for these so called polyQ diseases. Howeve...

Biochem. J. 461(1) , 137-46, (2014)

Oxidative-stress-induced necrosis is considered to be one of the main pathological mediators in various neurological disorders, such as brain ischaemia. However, little is known about the mechanism by which cells modulate necrosis in response to oxidative str...

World J. Microbiol. Biotechnol. 29(5) , 923-32, (2013)

The compound 3-nitropropionic acid is a potent neurotoxic agent in animals and well-known as a potent inhibitor of Mycobacterium tuberculosis. In this research, we were able to extract this compound from the endophytic fungus, Phomopsis longicolla (FJ62759), ...

Biochem. Biophys. Res. Commun. 441(2) , 280-5, (2013)

• Systemic infusion of 3-NP increased ROS and led striatal cell loss. • ASK1 down-regulation decreased striatal cell death without scavenging ROS. • Adding ASK1protein to SOD tg aggravated striatal degeneration. • ASK1 activation induced by ROS is an importan...

Neurosci. Bull. 28(5) , 517-31, (2012)

The aim of the present study was to determine the changes in the mRNA levels of neurotrophins and their receptors in the striatal tissue of mice treated with 3-nitropropionic acid (3-NP).At 1 and 48 h after the last drug administration, the mRNA expression of...