4-氨基-2-氯-6, 7-二氧基喹唑啉结构式
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常用名 | 4-氨基-2-氯-6, 7-二氧基喹唑啉 | 英文名 | 2-Chloro-6,7-dimethoxyquinazolin-4-amine |
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| CAS号 | 23680-84-4 | 分子量 | 239.658 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 374.0±42.0 °C at 760 mmHg | |
| 分子式 | C10H10ClN3O2 | 熔点 | 262-268 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 180.0±27.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
J. Med. Chem. 39 , 4602, (1996) The enantiomers of [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]-fu ran- 2-ylmethanone (cyclazosin, 1) were synthesized from the chiral furan-2-yl(cis-octahydroquinoxalin-1-yl)methanone [(+)-2 and (-)-2], which were obtained by reso... |
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2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.
J. Med. Chem. 30(10) , 1794-8, (1987) A series of 4-amino-6,7-dimethoxy-2(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for alpha-adrenoceptor affinity and antihypertensive activity. These quinazoline derivatives showed high binding affinity (ca. 10(-10) M) and selectivi... |
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2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.
J. Med. Chem. 30(6) , 999-1003, (1987) A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for alpha-adrenoceptor affinity and antihypertensive activity. These compounds displayed high binding affinity (Ki, 10(-9)-10(-10) M) and selectivity fo... |
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Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists.
J. Med. Chem. 42 , 427, (1999) A new series of novel piperazine and non-piperazine derivatives of 2, 4-diamino-6,7-dimethoxyquinazoline was synthesized and evaluated for binding affinity toward alpha1-adrenergic and other G-protein-coupled aminergic receptors. The alpha1-adrenoceptor (AR) ... |