N-乙酰-5-羟基色胺
N-乙酰-5-羟基色胺结构式
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常用名 | N-乙酰-5-羟基色胺 | 英文名 | N-Acetylserotonin |
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| CAS号 | 1210-83-9 | 分子量 | 218.252 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 556.8±40.0 °C at 760 mmHg | |
| 分子式 | C12H14N2O2 | 熔点 | 120-122 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 290.6±27.3 °C |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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The antioxidant behaviour of melatonin and structural analogues during lipid peroxidation depends not only on their functional groups but also on the assay system.
Biochem. Biophys. Res. Commun. 423(4) , 873-7, (2012) There is no general agreement yet on the antioxidant effect of pineal indoles against lipid peroxidation. Accordingly, the main goal of the present work was to study the antioxidant activity of melatonin (MLT), N-acetylserotonin (NAS), 5-HO-tryptophan (5HO-TR... |
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Clock-Controlled Regulation of the Acute Effects of Norepinephrine on Chick Pineal Melatonin Rhythms.
J. Biol. Rhythms 30 , 519-32, (2015) The chicken pineal gland synthesizes and releases melatonin rhythmically in light/dark (LD) cycles, with high melatonin levels during the dark phase, and in constant darkness (DD) for several cycles before it gradually damps to arrhythmicity in DD. Daily admi... |
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An UPLC-MS-based metabolomics investigation on the anti-fatigue effect of salidroside in mice.
J. Pharm. Biomed. Anal. 105 , 84-90, (2015) An ultra-performance liquid chromatography-quadrupole time-of-flight-based metabolomic approach was developed to study influence of salidroside, an anti-fatigue ingredient from Rhoiola rosea, on urinary metabolic profiling of rats to a single dose of 180 mg/k... |
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Antiplatelet aggregation and endothelial protection of I4, a new synthetic anti-diabetes sulfonylurea compound.
Platelets 26 , 342-8, (2015) I4 is a new synthetic anti-diabetes sulfonylurea compound. The aim of present study was to investigate the preventive effects and primary action mechanisms of I4 on platelet-mediated arterial thrombosis. Platelet aggregation and 5-hydroxytryptamine (5-HT) sec... |
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Changes in the content of brain biogenic amine associated with early colony establishment in the Queen of the ant, Formica japonica.
PLoS ONE 7(8) , e43377, (2012) We examined changes in the content of biogenic amines in the brains of ant queen associated with early colony establishment. In ants, including Formica japonica, winged virgin queens lose their wings following copulation, and then start establishing a colony.... |
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A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease.
PLoS ONE 9(2) , e87923, (2014) Huntington's disease (HD) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. HD is clinically characterized by chorea, emotional and psychiatric disturbances and cognitive deficits with l... |
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Sulfation of melatonin: enzymatic characterization, differences of organs, species and genders, and bioactivity variation.
Biochem. Pharmacol. 94(4) , 282-96, (2015) Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes. In metabolism pathways of Mel, 6-hydroxymelatonin-sulfate (S-O-Mel) and N-acetylserotonin sulfate (S-NAS) are the most abundant metabolites account for over 90% of total Mel... |
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N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.
Neuroscientist 18(6) , 645-53, (2012) N-Acetylserotonin (NAS) is a naturally occurring chemical intermediate in biosynthesis of melatonin. Previous studies have shown that NAS has different brain distribution patterns from those of serotonin and melatonin, suggesting that NAS might have functions... |
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Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
Hypertension 52(3) , 484-90, (2008) GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the balance of NO and superoxide produced by this enzyme. The aim... |