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3-酰脲丙酸

3-酰脲丙酸结构式
3-酰脲丙酸结构式
品牌特惠专场
常用名 3-酰脲丙酸 英文名 Ureidopropionic acid
CAS号 462-88-4 分子量 132.11800
密度 1.337g/cm3 沸点 324.8ºC at 760mmHg
分子式 C4H8N2O3 熔点 170-175ºC (dec.)
MSDS 中文版 美版 闪点 150.2ºC

Improved colorimetric procedure for quantitating N-carbamoyl-beta-alanine with minimum dihydrouracil interference.

Anal. Biochem. 122(2) , 345-7, (1982)

Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 791(1-2) , 371-80, (2003)

Enzyme deficiencies in pyrimidine metabolism are associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil. To assess whether urinary levels of pyrimidines and their metabolites can be used for predicting patients' individual ...

Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry.

J. Inherit. Metab. Dis. 28(6) , 1109-22, (2005)

To evaluate the significance of inborn metabolic disorders of the pyrimidine degradation pathway, 450 children with unspecific neurological symptoms were comprehensively studied; 200 healthy children were recruited as controls. Uracil and thymine as well as t...

3-Ureidopropionate contributes to the neuropathology of 3-ureidopropionase deficiency and severe propionic aciduria: a hypothesis.

J. Neurosci. Res. 66(4) , 666-73, (2001)

3-Ureidopropionate (3-UPA) is a physiologic metabolite in pyrimidine degradation. Pathological accumulation of 3-UPA in body fluids is found in 3-ureidopropionase deficiency and severe forms of propionic aciduria. Both diseases clinically present with a sever...

Assay for beta-ureidopropionase by high-performance liquid chromatography.

Anal. Biochem. 188(1) , 233-6, (1990)

A sensitive assay for beta-ureidopropionase based on derivatization of the reaction product beta-alanine with phenylisothiocyanate has been developed. Purification of the resulting phenylthiocarbamoyl-beta-alanine is achieved on a LiChrospher 100 C18 reversed...

Simple method for the quantitative analysis of dihydropyrimidines and N-carbamyl-beta-amino acids in urine.

Adv. Exp. Med. Biol. 309B , 15-9, (1991)

beta-Ureidopropionase deficiency: a novel inborn error of metabolism discovered using NMR spectroscopy on urine.

Magn. Reson. Med. 46(5) , 1014-7, (2001)

In this work, NMR investigations that led to the discovery of a new inborn error of metabolism, beta-ureidopropionase (UP) deficiency, are reported. 1D (1)H-NMR experiments were performed using a patient's urine. 3-Ureidopropionic acid was observed in elevate...

Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 839(1-2) , 45-53, (2006)

A liquid chromatography-tandem mass spectrometric assay for the determination of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine was developed to measure the activities of enzymes involved in pyrimidine breakdown. The assay was required to in...

Enzymes of uracil catabolism in normal and neoplastic human tissues.

Cancer Res. 45(11 Pt 1) , 5405-12, (1985)

Enzymes of the pyrimidine base catabolism, dihydrouracil dehydrogenase (EC 1.3.1.2), dihydropyrimidinase (EC 3.5.2.2), and beta-ureidopropionase (EC 3.5.1.6) were compared in the cytosolic extract of several normal and neoplastic human tissues. The activity w...

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.

Mol. Genet. Metab. 91(2) , 157-64, (2007)

Dihydropyrimidinase (DHP) is the second enzyme of the pyrimidine degradation pathway and it catalyses the ring opening of 5,6-dihydrouracil and 5,6-dihydrothymine to N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyric acid, respectively. To date, only...