4 -乙酰氨基酚硫酸钾盐
4 -乙酰氨基酚硫酸钾盐结构式
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常用名 | 4 -乙酰氨基酚硫酸钾盐 | 英文名 | paracetamol sulfate potassium salt |
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| CAS号 | 32113-41-0 | 分子量 | 269.31600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C8H8KNO5S | 熔点 | 163ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS05, GHS07 |
信号词 | Danger |
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Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen.
Blood 97(12) , 3846-50, (2001) In patients suspected of having drug-induced immune thrombocytopenia, antibodies reactive with normal platelets in the presence of the suspect drug can sometimes be identified, but negative results are often obtained. One reason for this is that drug metaboli... |
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Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Clin. Exp. Pharmacol. Physiol. 36(1) , 35-42, (2009) 1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in ... |
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Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study.
Bioanalysis 4(12) , 1429-43, (2012) In support of a pilot clinical trial using acetaminophen as the model compound to assess dried blood spot (DBS) sampling as the method for clinical pharmacokinetic sample collection, a novel sensitive LC-MS/MS method was developed and validated for the simult... |
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Spectrophotometric determination of paracetamol in urine with tetrahydroxycalix[4]arene as a coupling reagent and preconcentration with triton X-114 using cloud point extraction.
Chem. Pharm. Bull. 54(6) , 891-6, (2006) In the present paper, conventional spectrophotometry in conjunction with cloud point extraction-preconcentration were investigated as alternative methods for paracetamol (PCT) assay in urine samples. Cloud point extraction (CPE) was employed for the preconcen... |
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Disposition of acetaminophen and indocyanine green in cystic fibrosis-knockout mice.
AAPS PharmSci 2(2) , E18, (2000) Drug treatment poses a therapeutic challenge in cystic fibrosis (CF) because the disposition of a number of drugs is altered in CF. Enhanced clearance of acetaminophen (APAP) and indocyanine green (ICG) have previously been reported in CF patients. The object... |
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Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE.
Pharmacology 79(2) , 97-103, (2007) In addition to pathophysiological changes, genetic variations can alter drug pharmacokinetics in patients with thalassemia. Numerous drugs are metabolized by UDP-glucuronosyltransferases (UGT) including paracetamol (PCM), a widely used analgesic. Co-occurrenc... |
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The effects of phytoestrogenic isoflavones on the formation and disposition of paracetamol sulfate in the isolated perfused rat liver.
J. Pharm. Pharmacol. 55(5) , 639-46, (2003) This study examines the potential for the phytoestrogenic isoflavones, a type of complementary medicine, to be involved in pharmacokinetic interactions in the liver. Rat livers were isolated and perfused to steady state, in single-pass mode, with either 5 mic... |
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A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.
Eur. J. Clin. Pharmacol. 62(9) , 743-8, (2006) Thalassemia may alter the pharmacokinetics of several drugs in thalassemic patients. Paracetamol is a commonly used analgesic and antipyretic drug which is extensively metabolized in the liver via glucuronidation. The aim of this study was to compare the phar... |
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Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man.
J. Pharm. Pharmacol. 53(7) , 1041-5, (2001) The effect of cisapride on plasma concentrations of paracetamol was investigated with respect to hepatic metabolism. Paracetamol (1 g) together with cisapride (7.5 mg) or placebo was orally administered to five healthy male volunteers. Venous blood samples we... |
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Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters.
Biol. Pharm. Bull. 27(11) , 1792-6, (2004) The effect of taurine intake on the biliary disposition and toxicity of acetaminophen (APAP) was examined in male Golden-Syrian hamsters. Animals were provided with taurine (5 mM) in drinking water for 1 week followed by APAP treatment (250 mg/kg, i.p.). Bili... |