阿糖尿苷
阿糖尿苷结构式
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常用名 | 阿糖尿苷 | 英文名 | 1-β-D-Arabinofuranosyluracil |
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| CAS号 | 3083-77-0 | 分子量 | 244.201 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C9H12N2O6 | 熔点 | 220-222ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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N4-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine—New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate)
Bioorg. Med. Chem. 19(11) , 3520-6, (2011) New cytostatic antimetabolite-bisphosphonates. |
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Bioactive compounds from the fern Lepisorus contortus.
J. Nat. Prod. 74 , 129-36, (2011) Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syr... |
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Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.
Int. J. Med. Microbiol. 302(2) , 101-7, (2012) The importance of noninvasive imaging methods to bacterial infections is widely recognized. To obtain bacterial infection imaging with radioisotope-labeled nucleosides, bacterial thymidine kinase (tk) activities of Salmonella typhimurium with [(125)I]5-iodo-1... |
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Comparison of cell-labeling methods with ¹²⁴I-FIAU and ⁶⁴Cu-PTSM for cell tracking using chronic myelogenous leukemia cells expressing HSV1-tk and firefly luciferase.
Cancer Biother. Radiopharm. 27(10) , 719-28, (2012) Cell-tracking methods with molecular-imaging modality can monitor the biodistribution of cells. In this study, the direct-labeling method with ⁶⁴Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (⁶⁴Cu-PTSM), indirect cell-labeling methods with herpes simplex v... |
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Toxicology. 'Humanized' mouse detects deadly drug side effects.
Science 344(6181) , 244-5, (2014)
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Monitoring bone marrow stem cells with a reporter gene system in experimental middle cerebral artery occlusion rat models.
J. Nucl. Med. 54(6) , 984-9, (2013) This study was designed to investigate the feasibility of imaging bone marrow stem cells (BMSCs) in experimental middle cerebral artery occlusion (MCAO) rat models with a reporter gene-probe system, HSV1-tk-(131)I-2'-fluoro-2'-deoxy-1-β-d-arabinofuranosyl-5-i... |
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A multimodality reporter gene for monitoring transplanted stem cells.
Nucl. Med. Biol. 39(6) , 813-20, (2012) The aim of this study is to explore the feasibility of a triple-fused reporter gene, termed TGF [herpes simplex virus type 1 thymidine kinase (HSV1-tk), enhanced green fluorescent protein (eGFP) and firefly luciferase (Fluc)], to monitor stem cells using mult... |
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The improved syntheses of 5-substituted 2'-[18F]fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy.
Nucl. Med. Biol. 38(5) , 659-66, (2011) We and others have previously reported a four-step radiosynthesis of a series of 2'-deoxy-2'-[(18)F]fluoro-5-substituted-1-β-D-arabinofuranosyluracil derivatives including [(18)F]FAU, [(18)F]FEAU, [(18)F]FFAU, [(18)F]FCAU, [(18)F]FBAU and [(18)F]FIAU as thymi... |
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Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging.
Nucl. Med. Biol. 38(7) , 987-95, (2011) Herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene in combination with radiolabeled nucleoside substrates is the most widely used reporter system. This study characterized 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl)-5-iodocytosine ((18)F-FIAC)... |
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Patients with chronic hepatitis B treated with oral antiviral therapy retain a higher risk for HCC compared with patients with inactive stage disease.
Gut 63(12) , 1943-50, (2014) It is generally stated that oral antiviral therapy in patients with chronic hepatitis B (CHB) decreases the risk of developing hepatocellular carcinoma (HCC). Although oral nucleos(t)ide analogues (NUCs) may induce a state similar to inactive stage CHB, the l... |