六氯-1,3-丁二烯

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o...

J. Chromatogr. A. 1356 , 221-9, (2014)

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromatography (LV-DAI-GC) method was optimized for the following ...

J. Environ. Sci. Health. A. Tox. Hazard. Subst. Environ. Eng. 38(4) , 597-607, (2003)

To optimize the efficiency of bioremediation, treatability studies are needed to understand the fate of pollutants and environmental conditions under which microorganism growth is promoted and efficient degradation of these pollutants result. This article pre...

Environ. Technol. 25(4) , 443-50, (2004)

The efficacy of current landfill gas and radon mitigation measures for the prevention of ingress of organic vapours was investigated by the study of four houses situated on contaminated land in North West England. The chemical present in the ground of greates...

J. Appl. Toxicol. 32(6) , 417-28, (2012)

Hexachloro-1:3-butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5-90 mg kg⁻¹ to determin...

Rev. Environ. Contam. Toxicol. 101 , 121-37, (1988)

Toxicol. Lett. 182(1-3) , 84-90, (2008)

Gene expression of regucalcin (Rgn), a calcium-binding protein, was investigated in kidney of male Wistar rats treated with proximal tubule segment-specific nephrotoxicants, namely hexachloro-1:3-butadiene (HCBD), specific for S(3) segment (pars recta) and po...

Occup. Environ. Med. 60(7) , 463-7, (2003)

To determine the prevalence of proteinuira and enzymuria among a cohort of subjects exposed to hexachlorobutadiene (HCBD) in their homes and to determine whether there was a change in observed effects when exposure ceased.Residents underwent a health check, w...

Toxicol. Pathol. 35(2) , 270-5, (2007)

The correspondence between histopathological findings and segment-specific biomarkers was investigated in rats treated with segment-specific nephrotoxicants. Male Wistar rats were treated with a single injection of K2Cr2O7 (25 mg/kg s.c. in saline), cis-Pt (1...

Toxicol. Lett. 138(1-2) , 63-73, (2003)

Hexachloro-1,3-butadiene (HCBD) has been reported to be toxic to the rat kidney in a 2 year study at doses higher than 0.2 mg/kg/day. The toxicity is known to be a consequence of the metabolism of HCBD by glutathione conjugation and the renal beta-lyase pathw...