氢化奎宁结构式
|
常用名 | 氢化奎宁 | 英文名 | dihydroquinine |
|---|---|---|---|---|
| CAS号 | 522-66-7 | 分子量 | 326.433 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 498.4±30.0 °C at 760 mmHg | |
| 分子式 | C20H26N2O2 | 熔点 | 168-176ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 255.2±24.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.
Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012) The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and in vivo against Plasmodium falciparum malaria parasites. Th... |
|
|
Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).
J. Org. Chem. 77(16) , 7076-80, (2012) A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic system gave α-aminonitriles in excellent yields (up to 95%) a... |
|
|
Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 65(2) , 333-9, (2006) Geometric parameters, the vibrational frequencies and thermochemical values of benzoquinone and hydroquinone were computed using ab initio molecular orbital calculations (HF) and density function theory (B3LYP) methods with the 6-31G(d) basis set, respectivel... |
|
|
Monomorphic ventricular tachycardia due to Brugada syndrome successfully treated by hydroquinidine therapy in a 3-year-old child.
J. Cardiovasc. Electrophysiol. 17(1) , 97-100, (2006) Mutations in the SCN5A gene can cause Brugada syndrome, a genetically inherited form of idiopathic ventricular fibrillation. We describe the case of a 3-year-old child with a structurally normal heart presenting with monomorphic ventricular tachycardia. Her e... |
|
|
Inline pneumatically assisted atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry.
J. Mass Spectrom. 45(6) , 635-42, (2010) Atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI) is known to suffer from poor ion transfer efficiencies as compared to conventional vacuum MALDI (vMALDI). To mitigate these issues, a new AP-MALDI ion source utilizing a coaxial gas... |
|
|
Does abnormal neuronal excitability exist in myotonic dystrophy? I. Effects of the antiarrhythmic drug hydroquinidine on slow saccadic eye movements.
Neurol. Sci. 21(2) , 73-80, (2000) The abnormal neuronal excitability hypothesized in myotonic dystrophy (MD) might contribute to psychomotor and behavioral disturbances of MD patients. To gain new insights into the pathophysiology of MD, we determined whether the antiarrhythmic drug hydroquin... |
|
|
Does abnormal neuronal excitability exist in myotonic dystrophy? II. Effects of the antiarrhythmic drug hydroquinidine on apathy and hypersomnia.
Neurol. Sci. 21(2) , 81-6, (2000) An abnormal neuronal excitability in myotonic dystrophy (MD) might contribute to psychomotor and behavioral disturbances of MD patients. To gain new insights into the pathophysiology of MD, we determined whether the antiarrhythmic drug hydroquinidine could am... |
|
|
[Malignant fascicular ventricular tachycardia degenerating into ventricular fibrillation in a patient with early repolarization syndrome].
Ann. Cardiol. Angeiol. (Paris.) 61(4) , 292-5, (2012) A 45-year-old man was hospitalized for syncope due to fascicular ventricular tachycardia degenerating into ventricular fibrillation (VF). The electrocardiogram showed an early repolarization syndrome. The arrhythmia was repetitive and disappeared after oral h... |
|
|
[Early repolarisation with ventricular fibrillation in a young woman].
Presse Med. 42(4 Pt 1) , 474-9, (2013)
|
|
|
Short QT syndrome in infancy. Therapeutic drug monitoring of hydroquinidine in a newborn infant.
Br. J. Clin. Pharmacol. 72(6) , 982-4, (2011)
|