美雌醇
美雌醇结构式
|
常用名 | 美雌醇 | 英文名 | mestranol |
|---|---|---|---|---|
| CAS号 | 72-33-3 | 分子量 | 310.430 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 442.3±45.0 °C at 760 mmHg | |
| 分子式 | C21H26O2 | 熔点 | 153-155 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 190.8±23.0 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
|
|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
|
|
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
|
|
Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.
Toxicol. Sci. 141(1) , 78-89, (2014) In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenici... |
|
|
Ultrasonic-assisted derivatization of estrogenic compounds in a cup horn booster and determination by GC-MS.
J. Sep. Sci. 33(1) , 104-11, (2010) Cup horn boosters are miniaturized ultrasound baths that maximize efficiency and precision. The optimization of an ultrasonic-assisted derivatization step by means of a cup horn booster and the determination of estrone, 17beta-estradiol, estriol, 17alpha-ethy... |
|
|
[Comparative study of the effect of ethinyl estradiol and mestranol. Clinical data from the literature].
Quad. Clin. Ostet. Ginecol. 24(9) , 597-617, (1969)
|
|
|
Pharmacokinetics of ethinyl estradiol and mestranol.
Am. J. Obstet. Gynecol. 163(6 Pt 2) , 2114-9, (1990) Pharmacokinetally, a 50 micrograms oral dose of mestranol (which itself is inactive) is bioequivalent to a 35 micrograms dose of ethinyl estradiol. Physiologically, mestranol ranges from 50% to 100% of the activity of ethinyl estradiol, depending on the endpo... |
|
|
Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive.
Psychiatry Clin. Neurosci. 62(3) , 365, (2008)
|
|
|
Occurrence and photochemical degradation of 17alpha-ethinylestradiol in Acushnet River Estuary.
Chemosphere 63(9) , 1583-90, (2006) 17alpha-Ethinylestradiol (EE2), a major constituent of common contraceptive pills, and three other estrogenic hormones, estrone (E1), 17beta-estradiol (E2) and mestranol (MeEE2) have been determined in Acushnet River Estuary seawater using a GC-MS technique. ... |