盐酸氮卓斯汀

J. Pharm. Sci. 104(4) , 1409-20, (2015)

We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation bar...

Pharm. Dev. Technol. 19(7) , 813-23, (2014)

The use of mucoadhesive biopolymers is one of the best approaches to prolong the drug residence inside the cul-de-sac, consequently increasing the bioavailability. Thus, the focus of this work was to develop mucoadhesive microspheres to overcome the limitatio...

Mol. Med. Report. 12 , 6501-8, (2015)

Cyclin-dependent kinase 2 (CDK2) has been reported to be overexpressed in human colorectal cancer; it is responsible for the G1‑to‑S‑phase transition in the cell cycle and its deregulation is a hallmark of cancer. The present study was the first to use idock,...

J. Ethnopharmacol. 142(1) , 105-112, (2012)

The root of Panax ginseng CA Meyer (ginseng) has been used for diabetes, cancer, stress and allergic diseases in the traditional Chinese medicine.To understand the role of intestinal microflora in the pharmacological effect of ginsenoside Re, which is a main ...

Int. Arch. Allergy Immunol. 155(1) , 38-51, (2011)

Thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) are accepted to be important molecules in the development and maintenance of allergic diseases. Although several types of histamine H(1) receptor antagonist (antihistamin...

Acta Physiol. Hung. 99 , 173-184, (2012)

Novel strategies are evaluated for management of allergic rhinitis and asthma in patients co-afflicted with both disorders. It is hypothesized that the platelet activating factor receptor antagonist ginkgolide B (GB) and the carotenoid antioxidant astaxanthin...

Anal. Biochem. 484 , 105-12, (2015)

Ligand-gated ion channels (LGICs) are considered as attractive protein targets in the search for new therapeutic agents. Nowadays, this strategy involves the capability to screen large chemical libraries. We present a new Tag-lite ligand binding assay targeti...

Nat. Prod. Res. 26(23) , 2168-75, (2012)

From cultures of thermophilic soil fungus Humicola grisea var thermoidea, a δ-lactam derivative (3-(2-(4-hydroxyphenyl)-2-oxoethyl)-5,6-dihydropyridin-2(1H)-one) that displayed anti-allergic activity was isolated, which was predicted by in silico computationa...

ORL J. Otorhinolaryngol. Relat. Spec. 76(3) , 127-36, (2014)

The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF).Prima...

Dermatitis 22(6) , 354-7, (2011)