盐酸罗匹尼罗
盐酸罗匹尼罗结构式
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常用名 | 盐酸罗匹尼罗 | 英文名 | Ropinirole hydrochloride |
|---|---|---|---|---|
| CAS号 | 91374-20-8 | 分子量 | 296.836 | |
| 密度 | N/A | 沸点 | 410.5ºC at 760mmHg | |
| 分子式 | C16H25ClN2O | 熔点 | 241-243ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Sustained release microspheres of ropinirole hydrochloride: effect of process parameters.
Acta. Pharm. 61 , 363-376, (2011) An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose and PEG with the help of 32 full factorial design. The microspheres were made by incorporating the dr... |
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Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease
Neurobiol. Dis. 47(3) , 393-406, (2012) Dyskinesia seen in the off-state, referred as graft-induced dyskinesia (GID), has emerged as a serious complication induced by dopamine (DA) cell transplantation in parkinsonian patients. Although the mechanism underlying the appearance of GID is unknown, in ... |
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Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization.
J. Med. Chem. 55(12) , 5826-40, (2012) In our effort to develop multifunctional drugs against Parkinson's disease, a structure-activity-relationship study was carried out based on our hybrid molecular template targeting D2/D3 receptors. Competitive binding with [(3)H]spiroperidol was used to evalu... |
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Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy.
Ir. Med. J. 106(1) , 24-5, (2013) Impulse control disorders (ICDs) are a known side effect of dopamine replacement therapy in patients with Parkinson's disease (PD). They can have devastating consequences for patients and their families. |
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Ropinirole does not affect plasma arginine vasopressin levels in patients with advanced Parkinson's disease.
Neuro Endocrinol. Lett. 33(7) , 680-3, (2012) Several cases of syndrome of inappropriate antidiuresis induced by anti-Parkinson agents have been reported. Our previous study demonstrated that pergolide and pramipexole stimulated elevation of plasma arginine vasopressin (AVP) levels in some patients with ... |
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Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions.
PLoS Comput. Biol. 8(8) , e1002614, (2012) Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we combined a literature discovery approach with analysis of a large electronic medical record database method to predict and evaluate novel DDIs. We predicted an initial ... |
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ADMET considerations for restless leg syndrome drug treatments.
Expert Opin. Drug Metab. Toxicol. 8(10) , 1247-61, (2012) Restless legs syndrome (RLS) is a common neurological disorder that might impair nocturnal rest causing decreased alertness, depressed mood, reduced job performance, and poor quality of life. In patients affected by severe RLS, a pharmacological treatment is ... |
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Indirect comparisons of adverse events and dropout rates in early Parkinson's disease trials of pramipexole, ropinirole, and rasagiline.
Int. J. Neurosci. 122(7) , 345-53, (2012) The comparative safety profiles of monotherapeutic treatments for Parkinson's disease (PD) can provide valuable therapeutic information. The objective of this study was to perform an indirect comparison of Adverse Events (AEs) and Dropout Rates (DRs) among cl... |
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A fatal intoxication case involving ropinirole.
J. Forensic Leg. Med. 19(7) , 422-5, (2012) Ropinirole, a specific non-ergoline dopamine D2-receptor agonist, belongs to the drugs applied in treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) and acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. Thera... |
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Pharmacokinetics and effect of food after oral administration of prolonged-release tablets of ropinirole hydrochloride in Japanese patients with Parkinson's disease.
J. Clin. Pharm. Ther. 37(5) , 571-7, (2012) Ropinirole hydrochloride, a dopamine receptor agonist with a non-ergot alkaloid structure, is highly selective for the dopamine D(2) /D(3) receptors. This study was conducted to evaluate the steady-state pharmacokinetics, safety and efficacy after repeated or... |