L-365260
L-365260结构式
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常用名 | L-365260 | 英文名 | L-365,260 |
|---|---|---|---|---|
| CAS号 | 118101-09-0 | 分子量 | 398.45700 | |
| 密度 | 1.23g/cm3 | 沸点 | 611.5ºC at 760 mmHg | |
| 分子式 | C24H22N4O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 323.6ºC | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Combination pharmacotherapy for the treatment of neuropathic pain in adults.
Cochrane Database Syst. Rev. 7 , CD008943, (2012) Pharmacotherapy remains an important modality for the treatment of neuropathic pain. However, as monotherapy current drugs are associated with limited efficacy and dose-related side effects. Combining two or more different drugs may improve analgesic efficacy... |
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Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor.
J. Med. Chem. 48(1) , 180-91, (2005) The Cholecystokinin-1 receptor (CCK1R) mediates actions of CCK in areas of the central nervous system and of the gut. It is a potential target to treat a number of diseases. As for all G-protein-coupled receptors, docking of ligands into modeled CCK1R binding... |
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A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin.
Br. J. Pharmacol. 154(5) , 1009-15, (2008) Leptin regulates energy expenditure and body weight by acting both on the hypothalamus and on peripheral targets. Central actions of leptin are enhanced by cholecystokinin (CCK). The interaction between leptin and CCK makes physiological sense, as rats lackin... |
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Cholecystokinin action on layer 6b neurons in somatosensory cortex.
Brain Res. 1282 , 10-9, (2009) Layer 6b in neocortex is a distinct sublamina at the ventral portion of layer 6. Corticothalamic projections arise from 6b neurons, but few studies have examined the functional properties of these cells. In the present study we examined the actions of cholecy... |
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CCK(B) receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice.
Brain Res. Bull. 71(5) , 447-51, (2007) Cholecystokinin octapeptide (CCK-8) is a physiological antagonist of endogenous opioids in the central nervous system (CNS). Our previous work has shown that CCK-8 plays an important role in the development of tolerance to morphine analgesia and electroacupun... |
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Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice.
BMC Neurosci. 9 , 101, (2008) CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin (CCK) are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of leptin and CCK on food intake and our hypothesis on a co-ope... |
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Cellular action of cholecystokinin-8S-mediated excitatory effects in the rat periaqueductal gray.
Life Sci. 79(18) , 1702-11, (2006) The peptide cholecystokinin (CCK) is one of the major neurotransmitters modulating satiety, nociception, and anxiety behavior. Although many behavioral studies showing anti-analgesic and anxiogenic actions of CCK have been reported, less is known about its ce... |
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Mediators of glucagon-like peptide 2-induced blood flow: responses in different vascular sites.
Regul. Pept. 142(1-2) , 7-15, (2007) The aims of the present study were: to characterize the mechanisms of hemodynamic alterations induced by GLP-2, and, to compare the responses elicited in the superior mesenteric artery (SMA) to other vascular beds. Anesthetized rats were infused at the doses ... |
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Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
Pancreas 39(2) , 127-34, (2010) This study evaluated the role played by cholecystokinin (CCK) receptors' occupation in the control of somatostatin (SS) secretion in RIN-14B cells.The presence of the CCK receptors 1 and 2 was confirmed by immunofluorescence, and SS secretion was evaluated by... |
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Meningiomas expressing and responding to cholecystokinin (CCK).
J. Neurooncol. 73(3) , 199-204, (2005) The effect of cholecystokinin (CCK) on cultured human meningioma derived cells was investigated. Exposure of meningioma cells for 6-12 days to CCK-8s (2-200 nM) resulted in a dose dependent stimulation of cell growth to a maximum of 1.1-fold over basal contro... |