布雷菲德菌素A结构式
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常用名 | 布雷菲德菌素A | 英文名 | Brefeldin A |
|---|---|---|---|---|
| CAS号 | 20350-15-6 | 分子量 | 280.359 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 492.7±45.0 °C at 760 mmHg | |
| 分子式 | C16H24O4 | 熔点 | 200-205ºC | |
| MSDS | 中文版 美版 | 闪点 | 180.8±22.2 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.
MBio 5(5) , e01921-14, (2014) Pathogenic and nonpathogenic species of bacteria and fungi release membrane vesicles (MV), containing proteins, polysaccharides, and lipids, into the extracellular milieu. Previously, we demonstrated that several mycobacterial species, including bacillus Calm... |
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Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways.
J. Virol. 89(5) , 2698-709, (2015) CD4(+) T lymphocytes play a central role in the immune system and mediate their function after recognition of their respective antigens presented on major histocompatibility complex II (MHCII) molecules on antigen-presenting cells (APCs). Conventionally, phag... |
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Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection.
Infect. Immun. 82(7) , 3033-44, (2014) YopE is a virulence factor that is secreted into host cells infected by Yersinia species. The YopE C-terminal domain has GTPase-activating protein (GAP) activity. The YopE N-terminal domain contains an epitope that is an immunodominant CD8(+) T cell antigen d... |
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Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.
J. Immunol. 193(9) , 4527-36, (2014) The inhibitory receptor programmed death-1 (PD-1) has been shown to regulate CD8 T cell function during chronic SIV infection; however, its role on CD4 T cells, specifically in the gut-associated lymphoid tissue, is less well understood. In this study, we sho... |
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Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity.
Br. J. Nutr. 113(5) , 770-82, (2015) Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin replacement, the aim of the present study was to evaluate t... |
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Immunogenicity of coiled-coil based drug-free macromolecular therapeutics
Biomaterials 35(22) , 5886-96, (2014) A two-component CD20 (non-internalizing) receptor crosslinking system based on the biorecognition of complementary coiled-coil forming peptides was evaluated. Exposure of B cells to Fab’-peptide1 conjugate decorates the cell surface with peptide1; further exp... |
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Induction of Local Secretory IgA and Multifunctional CD4⁺ T-helper Cells Following Intranasal Immunization with a H5N1 Whole Inactivated Influenza Virus Vaccine in BALB/c Mice.
Scand. J. Immunol. 81 , 305-17, (2015) Avian influenza subunit vaccines have been shown to be poorly immunogenic, leading to the re-evaluation of the immunogenic and dose-sparing potential of whole virus vaccines. In this study, we investigated the immune responses after one or two doses of intram... |
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Immunomodulation therapy of diabetes by oral administration of a surfactin lipopeptide in NOD mice.
Vaccine 32(50) , 6812-9, (2014) Type 1 diabetes mellitus (T1DM) is considered an autoimmune disease, which can be attenuated by modulation of immune pathway from Th1- to Th2-type through vaccination. WH1fungin surfactin is a Bacillus-produced natural immunomodulator. NOD mice were orally tr... |
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Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
EMBO J. 33(23) , 2765-81, (2014) The protease activity of the paracaspase Malt1 has recently gained interest as a drug target for immunomodulation and the treatment of diffuse large B-cell lymphomas. To address the consequences of Malt1 protease inactivation on the immune response in vivo, w... |
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A high-throughput siRNA screen identifies genes that regulate mannose 6-phosphate receptor trafficking.
J. Cell Sci. 127(23) , 5079-92, (2014) The delivery of newly synthesized soluble lysosomal hydrolases to the endosomal system is essential for lysosome function and cell homeostasis. This process relies on the proper trafficking of the mannose 6-phosphate receptors (MPRs) between the trans-Golgi n... |