1,4-二羟基-2-萘甲酸结构式
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常用名 | 1,4-二羟基-2-萘甲酸 | 英文名 | 1,4-Dihydroxy-2-naphthoic acid |
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CAS号 | 31519-22-9 | 分子量 | 204.179 | |
密度 | 1.5±0.1 g/cm3 | 沸点 | 461.7±40.0 °C at 760 mmHg | |
分子式 | C11H8O4 | 熔点 | 220 °C (dec.)(lit.) | |
MSDS | 美版 | 闪点 | 247.1±23.8 °C | |
符号 |
GHS07 |
信号词 | Warning |
Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens.
J. Med. Chem. 50 , 3973-5, (2007) Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as meth... |
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Optimal aerobic cultivation method for 1,4-dihydroxy-2-naphthoic acid production by Propionibacterium freudenreichii ET-3.
J. Biosci. Bioeng. 102(3) , 198-205, (2006) To investigate the effects of oxygen supply on Propionibacterium freudenreichii ET-3 metabolism and 1,4-dihydroxy-2-naphthoic acid (DHNA) production in detail, the strain was cultured by switching from anaerobic condition to aerobic condition at 72 h (termed ... |
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2,5-dihydroxybenzyl and (1,4-dihydroxy-2-naphthyl)methyl, novel reductively armed photocages for the hydroxyl moiety.
J. Org. Chem. 72(24) , 9190-4, (2007) Irradiation of alcohols, phenols, and carboxylic acids "caged" with the 2,5-dihydroxybenzyl group or its naphthalene analogue results in the efficient release of the substrate. The initial byproduct of the photoreaction, 4-hydroxyquinone-2-methide, undergoes ... |
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Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli.
J. Bacteriol. 180(10) , 2782-7, (1998) A key reaction in the biosynthesis of menaquinone involves the conversion of the soluble bicyclic naphthalenoid compound 1, 4-dihydroxy-2-naphthoic acid (DHNA) to the membrane-bound demethylmenaquinone. The enzyme catalyzing this reaction, DHNA-octaprenyltran... |
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A derivative of the menaquinone precursor 1,4-dihydroxy-2-naphthoate is involved in the reductive transformation of carbon tetrachloride by aerobically grown Shewanella oneidensis MR-1.
Appl. Microbiol. Biotechnol. 63(5) , 571-7, (2004) Transformation of carbon tetrachloride (CT) by Shewanella oneidensis MR-1 has been proposed to involve the anaerobic respiratory-chain component menaquinone. To investigate this hypothesis a series of menaquinone mutants were constructed. The menF mutant is b... |
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Isolation and identification of a new bifidogenic growth stimulator produced by Propionibacterium freudenreichii ET-3.
Biosci. Biotechnol. Biochem. 66(3) , 679-81, (2002) We have found a new growth stimulator for bifidobacteria in the culture broth of Propionibacterium freudenreichii ET-3. The bifidogenic growth stimulator (BGS) was purified by Diaion HP-20 column chromatography and preparative HPLC. Spectroscopic methods incl... |
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Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12.
Environ. Microbiol. 11(1) , 149-58, (2009) In this study, we investigated the role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12. A mini-Tn5 transposon mutant of E. cloacae SLD1a-1, designated as 4E6, was isolated that had lost the abi... |
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Safety of high doses ofPropionibacterium freudenreichiiET-3 culture in healthy adult subjects
Regul Toxicol Pharmacol 60(2) , 262-7, (2011) Propionibacterium freudenreichii ET-3 (7025) culture, a cell-free product of whey fermentation by P. freudenreichii ET-3, has been shown to promote the growth of Bifidobacteria through the action of 1,4-dihydroxy-2-naphthoic acid (DHNA). Here we report the re... |
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Characterization of Escherichia coli men mutants defective in conversion of o-succinylbenzoate to 1,4-dihydroxy-2-naphthoate.
J. Bacteriol. 152(3) , 1132-7, (1982) Four independent menaquinone (vitamin K(2))-deficient mutants of Escherichia coli, blocked in the conversion of o-succinylbenzoate (OSB) to 1,4-dihydroxy-2-naphthoate (DHNA), were found to represent two distinct classes. Enzymatic complementation was observed... |
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Suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorption.
Osteoporos. Int. 21(8) , 1437-47, (2010) The main component of the metabolic by-products of fermentation by Propionibacterium freudenreichii ET-3 is 1,4-dihydroxy-2-naphthoic acid (DHNA), which has a naphthoquinone skeleton, as in vitamin K2. This study showed that DHNA improved bone mass reduction ... |