N-(甲氧基琥珀酰基)-丙氨酸-丙氨酸-脯氨酸-缬氨酸 氯甲基酮
N-(甲氧基琥珀酰基)-丙氨酸-丙氨酸-脯氨酸-缬氨酸 氯甲基酮结构式
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常用名 | N-(甲氧基琥珀酰基)-丙氨酸-丙氨酸-脯氨酸-缬氨酸 氯甲基酮 | 英文名 | SPCK |
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| CAS号 | 65144-34-5 | 分子量 | 502.98900 | |
| 密度 | 1.234g/cm3 | 沸点 | 809.4ºC at 760 mmHg | |
| 分子式 | C22H35ClN4O7 | 熔点 | 159-161ºC | |
| MSDS | 美版 | 闪点 | 443.3ºC |
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Comparison of the effects of methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone-inhibited neutrophil elastase with the effects of its naturally occurring mutationally inactivated homologue (HBP) on fibroblasts and monocytes in vitro.
APMIS 100(12) , 1073-80, (1992) The mature neutrophils in the circulation contain, besides the different proteases known for a long time, a recently discovered proteolytically inactive elastase homologue (HBP/CAP37/azurocidin). This homologue, which we have named HBP due to its strong affin... |
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Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments.
J. Biol. Chem. 272(17) , 11079-87, (1997) Incubation of polymorphonuclear cells (PMN), isolated from human peripheral blood, with either lipoprotein(a) (Lp(a)) or free apolipoprotein(a) (apo(a)), derived from the parent Lp(a), caused in both cases a multisite fragmentation of apo(a) inhibited by meth... |
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In vitro proteolysis of human plasma low density lipoproteins by an elastase released from human blood polymorphonuclear cells.
J. Biol. Chem. 261(5) , 2057-63, (1986) In vitro incubation of human plasma low density lipoproteins (LDL) with human blood polymorphonuclear cells (PMN) for 1 h at 37 degrees C resulted in an increased (2-4-fold) release into the medium of an enzymatic activity which co-eluted with LDL by column c... |
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Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Eur. Respir. J. 19(6) , 1136-41, (2002) Nonantimicrobial effects of antibiotics may contribute to their activity in the treatment of infective airway disease. The aim of this study was to identify antibiotics used for the treatment of infection in cystic fibrosis that may alter the activity of huma... |
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Proteolysis of gelatin-bound fibronectin by activated leukocytes: a role for leukocyte elastase.
J. Leukoc. Biol. 50(4) , 331-40, (1991) Fragmentation of subendothelial matrix-bound fibronectin by proteases released from stimulated leukocytes has been implicated in lung vascular injury. We studied the degradation of fibronectin bound to denatured collagen by inflammatory polymorphonuclear leuk... |
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Efficacy of serine protease inhibitors against Cryptosporidium parvum infection in a bovine fallopian tube epithelial cell culture system.
J. Parasitol. 82(4) , 638-40, (1996) The anticryptosporidial potential of the protease inhibitors alpha-1-antitrypsin (AAT), antipain, aprotinin, leupeptin, methoxysuccinyl-ala-ala-pro-valine chloromethylketone (MAAPVCK), soybean trypsin inhibitor (SBTI), and phenylmethylsulfonyl fluoride (PMSF)... |
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An inhibitor of leukocyte elastase prevents immune complex-mediated hemorrhage in the rat lung.
J. Pharmacol. Exp. Ther. 274(1) , 548-54, (1995) The typical reverse passive Arthus reaction (RPA) was attained in rats by the instillation of a rabbit antiovalbumin serum into the lungs and intravenous injection of ovalbumin. Instillation of antiserum alone caused accumulation of polymorphonuclear leukocyt... |
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Protective effect of specific elastase inhibitor in experimental pulmonary emphysema.
Schweiz. Med. Wochenschr. 114(25) , 918-20, (1984) The inhibitory effect of synthetic elastase inhibitor was studied in experimental emphysema. The development of emphysema was totally prevented by this substance. According to the authors' opinion the administration of synthetic elastase inhibitors can be con... |
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Prevention of elastase-induced emphysema by aerosol administration of a specific synthetic elastase inhibitor.
Eur. J. Respir. Dis. 64(6) , 442-8, (1983) The effect of a synthetic elastase inhibitor was studied in experimental emphysema. The development of emphysema was totally prevented by this material. In the authors' opinion the administration of synthetic elastase inhibitors can be considered as a new pos... |
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Elastase from activated human neutrophils activates procarboxypeptidase R.
Microbiol. Immunol. 46(3) , 225-30, (2002) Carboxypeptidase R (EC 3.4.17.20; CPR) is an unstable basic carboxypeptidase found in fresh serum in addition to carboxypeptidase N (CPN) which is a stable enzyme. CPR in fresh serum is generated from its zymogen (proCPR) during coagulation by trypsin-like en... |