SPCK

Modify Date: 2024-01-06 18:44:00

SPCK structure	Common Name	SPCK
	CAS Number	65144-34-5	Molecular Weight	502.98900
	Density	1.234g/cm3	Boiling Point	809.4ºC at 760 mmHg
	Molecular Formula	C₂₂H₃₅ClN₄O₇	Melting Point	159-161ºC
	MSDS	USA	Flash Point	443.3ºC

Use of SPCK

MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase[1].

Name	methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
Synonym	More Synonyms

Description	MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
References	[1]. Waki H, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6. [2]. Middelhoven PJ, Vet al. Different proteolytic mechanisms involved in Fc gamma RIIIb shedding from human neutrophils. Clin Exp Immunol. 2001 Jul;125(1):169-75.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

References

[1]. Waki H, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6.

[2]. Middelhoven PJ, Vet al. Different proteolytic mechanisms involved in Fc gamma RIIIb shedding from human neutrophils. Clin Exp Immunol. 2001 Jul;125(1):169-75.

Density	1.234g/cm3
Boiling Point	809.4ºC at 760 mmHg
Melting Point	159-161ºC
Molecular Formula	C₂₂H₃₅ClN₄O₇
Molecular Weight	502.98900
Flash Point	443.3ºC
Exact Mass	502.21900
PSA	150.98000
LogP	0.99930
Index of Refraction	1.513
Storage condition	20°C

SPCK MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Comparison of the effects of methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone-inhibited neutrophil elastase with the effects of its naturally occurring mutationally inactivated homologue (HBP) on fibroblasts and monocytes in vitro.

APMIS 100(12) , 1073-80, (1992)

The mature neutrophils in the circulation contain, besides the different proteases known for a long time, a recently discovered proteolytically inactive elastase homologue (HBP/CAP37/azurocidin). This...

Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments.

J. Biol. Chem. 272(17) , 11079-87, (1997)

Incubation of polymorphonuclear cells (PMN), isolated from human peripheral blood, with either lipoprotein(a) (Lp(a)) or free apolipoprotein(a) (apo(a)), derived from the parent Lp(a), caused in both ...

In vitro proteolysis of human plasma low density lipoproteins by an elastase released from human blood polymorphonuclear cells.

J. Biol. Chem. 261(5) , 2057-63, (1986)

In vitro incubation of human plasma low density lipoproteins (LDL) with human blood polymorphonuclear cells (PMN) for 1 h at 37 degrees C resulted in an increased (2-4-fold) release into the medium of...

methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate

MeOSuc-Ala-Ala-Pro-Val-CMK

Meosuc-aapv-cmk

Methoxy-suc-ala-ala-pro-val-chloromethyl ketone

Msaapvck

methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone

Elastase Inhibitor,SPCK

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone