长春质碱
长春质碱结构式
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常用名 | 长春质碱 | 英文名 | Catharanthine |
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| CAS号 | 2468-21-5 | 分子量 | 336.427 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 491.5±45.0 °C at 760 mmHg | |
| 分子式 | C21H24N2O2 | 熔点 | 138-140ºC | |
| MSDS | 美版 | 闪点 | 251.1±28.7 °C |
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Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.
J. Pharmacol. Exp. Ther. 345(3) , 383-92, (2013) Catharanthine is a constituent of anticancer vinca alkaloids. Its cardiovascular effects have not been investigated. This study compares the in vivo hemodynamic as well as in vitro effects of catharanthine on isolated blood vessels, vascular smooth muscle cel... |
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The leaf epidermome of Catharanthus roseus reveals its biochemical specialization.
Plant Cell 20(3) , 524-42, (2008) Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. Carborundum abrasion technique was used to ex... |
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Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry.
J. Sep. Sci. 34 , 2885-2892, (2011) Catharanthus roseus is an important dicotyledonous medicinal plant that contains various anticancer components, such as vinblastine (VLB) and its monomeric precursors (vindoline and catharanthine). A capillary electrophoresis-mass spectrometry (CE-MS) approac... |
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Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.
Bioorg. Med. Chem. Lett. 20(22) , 6408-10, (2010) The examination of the catharanthine C16 substituent effects on the Fe(III)-promoted biomimetic coupling reaction with vindoline is detailed, confirming the importance of the presence of a C16 electron-withdrawing substituent, and establishing an unanticipate... |
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Synergistic and cytotoxic action of indole alkaloids produced from elicited cell cultures of Catharanthus roseus.
Pharm. Biol. 51(3) , 304-10, (2013) Catharanthus roseus (L.) G. Don (Apocynaceae) is a medicinal plant that produces more than 130 alkaloids, with special attention given to the production of the anti-hypertensive monomeric indole alkaloids, serpentine and ajmalicine, and the antitumor dimeric ... |
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Synthesis of difluorocatharanthine and investigation of its biomimetic coupling with vindoline.
Chemistry 19(4) , 1170-3, (2013)
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Synthesis of fluorinated catharanthine analogues and investigation of their biomimetic coupling with vindoline.
Org. Biomol. Chem. 11(35) , 5885-91, (2013) The syntheses of 20,20-difluorocatharanthine and congeners, starting from the naturally occurring catharanthine, are reported. The fluorinated catharanthine analogues were investigated as potential precursors to dimeric Vinca alkaloids of the vinflunine famil... |
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Elaboration of simplified vinca alkaloids and phomopsin hybrids.
Chem. Biol. Drug Des. 75(3) , 284-94, (2010) Nine simplified vinca alkaloids and phomospin A hybrids, in which vindoline moiety has been replaced by a simpler scaffold, have been elaborated to evaluate their activity on the inhibition of tubulin polymerization. This article deals with the synthesis of v... |
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A differential response to chemical elicitors in Catharanthus roseus in vitro cultures.
Biotechnol. Lett. 31(4) , 591-5, (2009) The effects of methyl jasmonate, salicylic acid and ethylene on alkaloid accumulation in in vitro cell suspension, hairy roots and rootless shoot cultures of Catharanthus roseus were analyzed. Ajmalicine, but not catharanthine, accumulation was promoted by ja... |
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Negative-pressure cavitation extraction of four main vinca alkaloids from Catharanthus roseus leaves.
Molecules 17(8) , 8742-52, (2012) In the present study, an improved method termed negative-pressure cavitation extraction (NPCE) followed by reverse phase high-performance liquid chromatography (RP-HPLC) was developed for the extraction and quantification of vindoline (VDL), catharanthine (CT... |