(+)-3-HYDROXYMORPHINAN HYDROBROMIDE
(+)-3-HYDROXYMORPHINAN HYDROBROMIDE结构式
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常用名 | (+)-3-HYDROXYMORPHINAN HYDROBROMIDE | 英文名 | (+)-3-HYDROXYMORPHINAN HYDROBROMIDE |
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| CAS号 | 15676-23-0 | 分子量 | 243.34400 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C16H21NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study.
Biomed. Chromatogr. 23(11) , 1131-7, (2009) Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity in vivo and in vitro. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3-methoxymorphinan and 3... |
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Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.
J. Pharm. Biomed. Anal. 54(2) , 387-94, (2011) A rapid and sensitive ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the simultaneous quantitative determination of dextromethorphan (DM) and its metabolites dextrorphan (DX), 3-methox... |
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Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 819(1) , 105-13, (2005) A rapid, sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method was developed for the simultaneous assay of dextromethorphan and its metabolites in tissue culture medium and its intestinal metabolism studied with the rat everted gut sa... |
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New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice.
Life Sci. 72(16) , 1883-95, (2003) Interest in dextromethorphan (DM) has been renewed because of its anticonvulsant and neuroprotective properties. However, DM at supra-antitussive doses can produce psychotomimetic effects in humans. Recently, we demonstrated that DM exerts psychotropic effect... |
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Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism.
J. Pharm. Sci. 98(2) , 763-71, (2009) Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo. The sequential metabolism of DOR during in vitro studies, particularly... |
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Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects.
J. Pharmacol. Sci. 106(1) , 22-7, (2008) Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulati... |
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Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan.
Neurochem. Int. 54(8) , 526-34, (2009) Dextromethorphan (DM), a widely used antitussive, has demonstrated an effective neuroprotective effect. Excessive release of glutamate is considered to be an underlying cause of neuronal damage in several neurological diseases. In the present study, we invest... |
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Pharmacokinetics and polymorphic oxidation of dextromethorphan in a Japanese population.
Biopharm. Drug Dispos. 17(5) , 421-33, (1996) The plasma concentration and cumulative urinary excretion over 34 h of dextromethorphan, free and conjugated dextrorphan, and 3-hydroxymorphinan were determined in seven healthy Japanese subjects after oral administration of 30 mg dextromethorphan hydrobromid... |
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Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM).
Chem. Pharm. Bull. 56(7) , 985-7, (2008) Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synt... |
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High-performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up.
J. Chromatogr. A. 420(1) , 217-22, (1987)
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