Philanthotoxin 343
Philanthotoxin 343结构式
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常用名 | Philanthotoxin 343 | 英文名 | Philanthotoxin 343 |
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| CAS号 | 115976-93-7 | 分子量 | 435.60300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C23H41N5O3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors
Eur. J. Pharmacol. 686(1-3) , 22-31, (2012) The GluN3 subunits of the N-methyl-d-aspartate (NMDA) receptor are known to reduce its Ca2+ permeability and Mg2+ sensitivity, however, little is known about their effects on other channel blockers. cRNAs for rat NMDA receptor subunits were injected into Xeno... |
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Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343.
J. Med. Chem. 39(2) , 515-21, (1996) Acid-base properties (pKa values and proton distribution patterns) of philanthotoxin-343(PhTX-343) were investigated by 1H and 13C NMR titration. Chemical shift data and the total ionization shifts were used to assign carbon atoms of the polyamine chain. Nonl... |
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A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues.
Eur. J. Med. Chem. 38(1) , 117-22, (2003) A general, improved procedure for rapid synthesis of philanthotoxin analogues, a pharmacologically important class of polyamine conjugates, is described. The solution-phase procedure is illustrated by gram-scale synthesis of philanthotoxins PhTX-343 and PhTX-... |
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Potent and voltage-dependent block by philanthotoxin-343 of neuronal nicotinic receptor/channels in PC12 cells.
Br. J. Pharmacol. 122(2) , 379-85, (1997) 1. Block by philanthotoxin-343 (PhTX-343), a neurotoxin from wasps, of ionic currents mediated through neuronal nicotinic acetylcholine (ACh) receptor/channels was characterized in rat phaeochromocytoma PC12 cells, by use of whole cell voltage-clamp technique... |
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Possible influence of intramolecular hydrogen bonds on the three-dimensional structure of polyamine amides and their interaction with ionotropic glutamate receptors.
Receptors Channels 7(3) , 227-36, (2000) Polyamine amides are potent antagonists of many classes of ionotropic receptor. Here, calculations of the conformations of 26 polyamine amides using molecular mechanics methodology have shown that intramolecular hydrogen bonds strongly influence the in vacuo ... |
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NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA-evoked striatal acetylcholine but not spermidine release.
J. Neurochem. 64(5) , 2043-8, (1995) NMDA receptor stimulation concomitantly increases the release of [14C]acetylcholine and [3H]-spermidine from rat striatal slices in vitro. The NMDA-induced release of both acetylcholine and spermidine was blocked with equal potency by the NMDA channel blocker... |
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Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.
Biophys. J. 87(1) , 159-70, (2004) Models of closed and open channel pores of a muscle-type nicotinic acetylcholine receptor (nAChR) channel comprising M1 and M2 segments are presented. A model of the closed channel is proposed in which hydrophobic residues of the Equatorial Leucine ring scree... |
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Multiple actions of arylalkylamine arthropod toxins on the N-methyl-D-aspartate receptor.
Neuroscience 70(2) , 361-75, (1996) The effects of the arylalkyamine arthropod toxins argiotoxin 636 and philanthotoxin 343 were studied on N-methyl-D-aspartate receptor currents in cultured rat hippocampal neurons using whole-cell recording techniques. Argiotoxin 636 and philanthotoxin 343 blo... |
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Synthesis and paralytic activities of squaryl amino acid-containing polyamine toxins.
Amino Acids 24(3) , 293-301, (2003) Eight analogs 4A-7A and 4B-7B of philanthotoxin (PhTX) from wasp venom and nephilatoxin-8 (NPTX-8) from spider venom whose tyrosine or asparagine linker is replaced by squaryl (sq) amino acid or 4-amino squaryl (4-asq) amino acid have been synthesized in an e... |
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Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
Chirality 12(2) , 93-102, (2000) PhTX-343 and PhTX-12, analogues of the natural polyamine wasp toxin PhTX-433, were synthesised in 40-60% yields as pure enantiomers using solid phase synthesis techniques. Capillary electrophoresis procedures were developed for chiral separation and determina... |