DL-高半胱氨酸硫内酯盐酸盐
DL-高半胱氨酸硫内酯盐酸盐结构式
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常用名 | DL-高半胱氨酸硫内酯盐酸盐 | 英文名 | 3-Aminodihydro-2(3H)-thiophenone hydrochloride |
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| CAS号 | 6038-19-3 | 分子量 | 153.630 | |
| 密度 | 0.862 g/cm3 | 沸点 | 253.8ºC at 760 mmHg | |
| 分子式 | C4H8ClNOS | 熔点 | 202 °C (dec.)(lit.) | |
| MSDS | 美版 | 闪点 | 107.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Water determination in active pharmaceutical ingredients using ionic liquid headspace gas chromatography and two different detection protocols.
J. Pharm. Biomed. Anal. 94 , 111-7, (2014) A rapid, accurate, precise and versatile analytical method was developed for the detection and quantification of water in solid active pharmaceutical ingredients (APIs). The headspace gas chromatography (HSGC) method utilized an ionic liquid (IL) based open t... |
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Comparison of the effect of homocysteine in the reduced form, its thiolactone and protein homocysteinylation on hemostatic properties of plasma.
Thromb. Res. 127(3) , 214-9, (2011) Mechanisms involved in the relationship between hyperhomocysteinemia and hemostatic process are still unclear. In the literature there are few papers describing studies on the effects of homocysteine (Hcys) on proteins that participate in blood coagulation an... |
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Response of blood platelets to resveratrol during a model of hyperhomocysteinemia.
Platelets 22(4) , 277-83, (2011) Resveratrol (3,4',5-trihydroxystilben), a phenolic antioxidant synthesized in grapes and other plants, and also present in wine, has been suggested to help prevent cardiovascular events. In this study the influence of resveratrol on platelet aggregation durin... |
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The enhancing effect of homocysteine thiolactone on insulin fibrillation and cytotoxicity of insulin fibril
Int. J. Biol. Macromol. 51(3) , 291-8, (2012) Highlights ► Homocysteine thiolactone (HCTL) augmented rate of insulin unfolding, increased solvent-exposed hydrophobic regions and induced a transition from α-helix into predominantly β-sheet structure. ► HCTL markedly enhanced the quantity of insulin fibril... |
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Quality control in tRNA charging -- editing of homocysteine.
Acta Biochim. Pol. 58 , 149-163, (2011) All living organisms conduct protein synthesis with a high degree of accuracy maintained in the transmission and flow of information from a gene to protein product. One crucial 'quality control' point in maintaining a high level of accuracy is the selectivity... |
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Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats.
Med. Chem. 8(1) , 59-64, (2012) Nitric oxide (NO), one of the gaseous neurotransmitters, is produced in reaction catalyzed by family of NO synthases (NOS). The involvement of neuronal NOS (nNOS) in seizures induced by homocysteine thiolactone has not been studied. Therefore, the aim of this... |
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Homocysteine and its thiolactone impair plasmin activity induced by urokinase or streptokinase in vitro.
Int. J. Biol. Macromol. 50(3) , 754-8, (2012) Mechanisms of homocysteine (Hcy) contribution to thrombosis are complex and only partly recognized. The available data suggest that the prothrombotic activity of homocysteine may be not only a result of the changes in coagulation process and endothelial dysfu... |
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The disturbance of hemostasis induced by hyperhomocysteinemia; the role of antioxidants.
Acta Biochim. Pol. 59(2) , 185-94, (2012) Elevated concentration of homocysteine (Hcy) in human tissues, definied as hyperhomocysteinemia has been correlated with some diseases, such as cardiovascular, neurodegenerative, and kidney disorders. Homocysteine occurs in human blood plasma in several forms... |
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The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart.
Mol. Cell Biochem. 370(1-2) , 59-67, (2012) Research on the effects of homocysteine on the vascular wall, especially in endothelial and smooth muscle cells, has indicated that increased homocysteine levels lead to cellular stress and cell damage. Considering the adverse effects of homocysteine on vascu... |
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Paraoxonase 1 and homocysteine metabolism.
Amino Acids 43(4) , 1405-17, (2012) Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and homocysteine (Hcy). Both PON1 and Hcy have been implicated in human diseases, including atheroscle... |