奥拉西坦

奥拉西坦结构式
奥拉西坦结构式
品牌特惠专场
常用名 奥拉西坦 英文名 Oxiracetam
CAS号 62613-82-5 分子量 158.155
密度 1.4±0.1 g/cm3 沸点 494.6±40.0 °C at 760 mmHg
分子式 C6H10N2O3 熔点 165-168ºC
MSDS 中文版 美版 闪点 252.9±27.3 °C
符号 GHS07
GHS07
信号词 Warning

Minaprine, but not oxiracetam, prevents desipramine-induced impairment of avoidance learning in mice.

Pol. J. Pharmacol. 47(1) , 69-73, (1995)

The tricyclic antidepressant desipramine impaired shuttle-box avoidance acquisition in mice of the CD-1 strain. The nootropic drug oxiracetam was unable to prevent the desipramine-induced learning impairment, while a protective action was exerted by minaprine...

Pre- and postprandial pyridostigmine and oxiracetam effects on growth hormone secretion in anorexia nervosa.

Psychoneuroendocrinology 21(7) , 621-9, (1996)

Previous studies have shown that food ingestion is not capable of inhibiting the GHRH-induced GH release in anorexia nervosa, at variance with what is observed in normal subjects. Moreover, a cholinergic alteration has been hypothesized in this disorder. In a...

Putative cognition enhancers reverse kynurenic acid antagonism at hippocampal NMDA receptors.

Eur. J. Pharmacol. 272(2-3) , 203-9, (1995)

Oxiracetam, aniracetam and D-cycloserine, three putative cognition enhancers, were examined in a functional assay for NMDA receptors. Rat hippocampal slices or synaptosomes were labeled with [3H]noradrenaline and exposed to NMDA or glutamate in superfusion. N...

Relationships between arousal and cognition-enhancing effects of oxiracetam.

Pharmacol. Biochem. Behav. 47(2) , 283-7, (1994)

Cognition-enhancing effects of no-otropic drugs are currently ascribed to an increase in arousal level. In order to test this hypothesis, we studied the effects of three doses of oxiracetam (25, 50 and 100 mg/kg IP) on a radial maze task and on slow wave slee...

Enhancement of contextual fear-conditioning by putative (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-D-aspartate (NMDA) receptor antagonists in DBA/2J mice.

Brain Res. 768(1-2) , 197-207, (1997)

Previous studies demonstrated that DBA/2J (DBA) mice performed poorly while C57BL/6J (C57) mice performed normally on a number of complex learning and memory tasks. Chronic oxiracetam treatment dramatically improved the performance of DBA mice but not that of...

Effect of alaptide, its analogues and oxiracetam on memory for an elevated plus-maze in mice.

Eur. J. Pharmacol. 314(1-2) , 1-7, (1996)

In the present study, the elevated plus-maze was used to evaluate memory in female mice. In Experiment 1, the mice retested on day 1, 4 or 7 after the initial session escaped from the open arm into the enclosed arm in a significantly shorter time than those r...

Determination of oxiracetam in human plasma by reversed-phase high-performance liquid chromatography with fluorimetric detection.

J. Chromatogr. A. 631(1-2) , 227-32, (1993)

Reversed-phase HPLC methodology utilizing pre-column derivatization and post-column reaction fluorimetric detection has been developed and applied to the determination of oxiracetam in human plasma. The method involves preliminary isolation of oxiracetam and ...

Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro.

Pol. J. Pharmacol. 51(6) , 485-95, (1999)

The nootropic drugs, including piracetam (PIR) and oxiracetam (OXI) are used in the adjunctive treatment of dementia. They are thought to directly influence energetic processes in the brain and, therefore, they are supposed to improve memory and cognition. Th...

Oxiracetam prevented the scopolamine but not the diazepam induced memory deficits in mice.

Behav. Brain Res. 133(2) , 395-9, (2002)

In mice, the elevated plus-maze paradigm was used to investigate the effect of scopolamine hydrobromide and diazepam and their interaction with oxiracetam on the retrieval of spatial memory trace. This paradigm measures (using the transfer latency) an animal'...

Determination of piracetam in rat plasma by LC-MS/MS and its application to pharmacokinetics.

Biomed. Chromatogr. 24(10) , 1108-12, (2010)

A sensitive and selective liquid chromatography-tandem mass spectrometry method for the determination of piracetam in rat plasma was developed and validated over the concentration range of 0.1-20 µg/mL. After addition of oxiracetam as internal standard, a sim...