(D-PYR1,D-PHE2,D-TRP3·6)-LHRH
(D-PYR1,D-PHE2,D-TRP3·6)-LHRH结构式
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常用名 | (D-PYR1,D-PHE2,D-TRP3·6)-LHRH | 英文名 | [DGlp1,DPhe2,DTrp3,6]-LH-RH |
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| CAS号 | 68059-94-9 | 分子量 | 1321.48000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C67H84N16O13 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS08 |
信号词 | Danger |
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Characterization of Leydig cell gonadotropin-releasing hormone binding sites utilizing radiolabeled agonist and antagonist.
Peptides 3(5) , 789-92, (1982) Gonadotropin-releasing hormone (GnRH) binding sites in intact Leydig cells and in membrane preparations were investigated using 125I-labeled GnRH agonist and antagonist. Binding was saturable and involved a single class of high affinity sites. Intact Leydig c... |
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Role of lipids in gonadotropin releasing hormone agonists and antagonist binding to rat pituitary.
Biochem. Biophys. Res. Commun. 105(1) , 8-13, (1982) Digestion of pituitary membranes with phospholipase A 2 and phospholipase C abolished, in a dose responsive manner, the specific binding of gonadotropin releasing hormone agonist and antagonist. These reductions in gonadotropin releasing hormone binding capac... |
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LH-RH analogue acts as substance P antagonist by inhibiting spinal cord vasomotor responses.
Brain Res. 337(2) , 357-61, (1985) Intrathecal injections of the luteinizing hormone-releasing hormone (LH-RH) analogue, [D-pGlu1-D-Phe2-D-Trp3,6]-LH-RH caused dose-dependent decreases in mean arterial blood pressure in anesthetized rats similar to those seen with [D-Pro4-D-Trp7,9]-substance P... |
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Indirect evidence for a physiological role exerted by a "testicular gonadotropin-releasing hormone" in the frog, Rana esculenta.
Gen. Comp. Endocrinol. 79(1) , 147-53, (1990) The possible physiological role of a putative testicular gonadotropin-releasing hormone (GnRH)-like material was studied in the frog, Rana esculenta. We have investigated (a) changes of mitotic index (MI) of primary spermatogonia (SPG) in GnRH agonist (GnRH-A... |
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Jun localization in cytosolic and nuclear compartments in brain-pituitary system of the frog, Rana esculenta: an analysis carried out in parallel with GnRH molecular forms during the annual reproductive cycle.
Gen. Comp. Endocrinol. 135(3) , 310-23, (2004) The presence of c-jun like mRNA was assessed in the brain of the frog, Rana esculenta, during the annual sexual cycle. In parallel, Jun protein and GnRH molecular form (mammalian and chicken II also indicated as GnRH1 and GnRH2, respectively) activity was stu... |
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Microinjection of LHRH and its antagonistic analog into the medial preoptic area does not affect pulsatile secretion of LH in ovariectomized rats.
Endocr. J. 41(5) , 559-63, (1994) To gain a better understanding of the existence of an ultra-short feedback mechanism controlling LHRH secretion in the medial preoptic area (MPO), we examined the effects of microinjections of LHRH or the LHRH antagonist [D-pGlu1, D-Phe2, D-Try3,6] into the M... |
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Androgen and progestogen production by prepubertal rat interstitial cells: study of the effects of LHRH and its analogues and their interactions with LH.
Mol. Cell. Endocrinol. 34(1) , 7-16, (1984) The effects of luteinizing hormone-releasing hormone (LHRH) and an agonistic analogue (LHRHa) have been examined in freshly isolated prepubertal rat interstitial cells and in cells precultured for 6 days in the presence or absence of luteinizing hormone (LH).... |
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Luteinizing hormone-releasing hormone enhances polyphosphoinositide breakdown in rat granulosa cells.
Biochem. Biophys. Res. Commun. 130(3) , 1201-8, (1985) A 2-min addition of LHRH to [3H]inositol-prelabeled rat granulosa cells in primary culture evoked significant increases in the accumulation of [3H]inositol phosphates, i.e. radiolabeled inositol monophosphate (IP), inositol diphosphate (IP2), and inositol tri... |
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LHRH stimulates plasminogen activator and inhibits steroid production by granulosa cells of adult rat Graafian follicles.
Mol. Cell. Endocrinol. 44(1) , 61-8, (1986) We studied the effects of LHRH and its analogs on plasminogen activator production and progesterone and estradiol secretion by granulosa cells isolated from adult rat Graafian follicles. LHRH and its agonist ([des- -Gly10,D-Trp6,Pro9-NHEt]LHRH) stimulated sma... |
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Modulation of lordosis behavior of female rats by naloxone, beta-endorphin and its antiserum in the mesencephalic central gray: possible mediation via GnRH.
Neuroendocrinology 39(3) , 222-30, (1984) The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-prog... |