[Des-His1,Glu9]-Glucagon amide
![[Des-His1,Glu9]-Glucagon amide结构式](https://image.chemsrc.com/caspic/470/110084-95-2.png)
[Des-His1,Glu9]-Glucagon amide结构式
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常用名 | [Des-His1,Glu9]-Glucagon amide | 英文名 | (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine) |
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| CAS号 | 110084-95-2 | 分子量 | 3358.650 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C148H221N41O47S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Mol. Endocrinol. 19 , 198-212, (2005) Glucagon, secreted by the pancreatic alpha-cells, stimulates insulin secretion from neighboring beta-cells by cAMP- and protein kinase A (PKA)-dependent mechanisms, but it is not known whether glucagon also modulates its own secretion. We have addressed this ... |
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Glucagon receptors on human islet cells contribute to glucose competence of insulin release.
Diabetologia 43 , 1012-1019, (2000) Synergism between glucose and cAMP in the stimulation of insulin secretion has been suggested to regulate beta cells. This study assessed the importance of an interaction between glucose and cAMP in the stimulation of insulin secretion from human islet cells ... |
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Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.
Peptides 10 , 1171, (1989) Hyperglycemia in diabetes mellitus is generally associated with elevated levels of glucagon in the blood. A glucagon analog, des-His1[Glu9]glucagon amide, has been designed and synthesized and found to be an antagonist of glucagon in several systems. It has b... |
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Evidence for a potential role of glucagon during eye growth regulation in chicks.
Vis. Neurosci. 19 , 755-766, (2002) Eye growth and refraction are regulated by visual processing in the retina. Until now, the messengers released by the retina to induce these changes are largely unknown. Previously, it was found that glucagon amacrine cells respond to defocus in the retinal i... |
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Potentiation of glucose-induced insulin release in islets by desHis1[Glu9]glucagon amide.
Int. J. Pept. Protein Res. 32(6) , 436-40, (1988) Glucagon and secretin and some of their hybrid analogs potentiate glucose-induced release of insulin from isolated mouse pancreatic islets. It was recently shown that the synthetic glucagon analog, desHis1[Glu9]glucagon amide, does not stimulate the formation... |
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Glucagon-like peptide-1 inhibits insulinotropic effects of oxyntomodulin and glucagon in cattle.
Domest. Anim. Endocrinol. 42(3) , 155-64, (2012) Oxyntomodulin (OXM), glucagon, and glucagon-like peptide-1 (GLP-1), peptide hormones derived from the glucagon gene, play an important role in glucose homeostasis. The insulinotropic action of these three homologous peptides has been well documented in monoga... |