(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐
(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐结构式
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常用名 | (±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐 | 英文名 | 8-hydroxy-dpat hydrobromide |
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| CAS号 | 87394-87-4 | 分子量 | 328.28800 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C16H26BrNO | 熔点 | 221.5-222 °C | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats.
Vascul. Pharmacol. 72 , 172-80, (2015) Although serotonin has been shown to inhibit peripheral sympathetic outflow, serotonin regulation on renal sympathetic outflow has not yet been elucidated. This study investigated which 5-HT receptor subtypes are involved. Wistar rats were anesthetized (sodiu... |
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Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats.
Clin. Exp. Pharmacol. Physiol. 42 , 640-7, (2015) 5-HT is a powerful vasoconstrictor substance in renal vasculature (mainly by 5-HT₂ activation). Nevertheless, 5-HT is notable for its dual cardiovascular effects, producing both vasodilator and vasoconstrictor actions. This study aimed to investigate whether,... |
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Serotonin 5-HT1A receptor in infancy-onset aggression: comparison with genetically defined aggression in adult rats.
Behav. Brain Res. 243 , 97-101, (2013) Antisocial aggressive behavior in adolescents represents growing clinical and social problem. Previously the implication of 5-HT1A receptor in the regulation of fear-induced aggression was shown. Here, the involvement of 5-HT1A receptor in infancy-onset genet... |
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Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1Aactivity, Part 1
Eur. J. Med. Chem. 44 , 1710-7, (2009) A series of new derivatives of 4-aryl-pyrido[1,2- c]pyrimidine containing the 3-(4-piperidyl)-1 H-indole residue or its 5-methoxy derivative were synthesized. They were characterized ( i) in vitro by binding to 5-HT 1A receptors and 5-HT transporter proteins ... |
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Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1.
Eur. J. Med. Chem. 46 , 4474-88, (2011) The synthesis, structure, in vitro and in vivo pharmacological activities of 3β-acylamine derivatives of tropane (4a-n, 5a-g, 6a,b, 8a-c) are described. Among the investigated compounds, several displayed very high (in nM) affinity for the monoamine receptors... |
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Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT(1A) receptor stimulation in the rat.
Neurochem. Int. 61(8) , 1344-56, (2012) This study examined the firing rate and pattern of electrophysiologically and chemically identified GABA interneurons in the dorsal raphe nucleus (DRN), and role of 5-HT(1A) receptor agonist 8-OH-DPAT and the medial prefrontal cortex (mPFC) in the firing acti... |
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Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus.
J. Physiol. Sci. 63(2) , 147-54, (2013) The dorsal raphe nucleus (DRN) is the origin of the central serotonin [5-hydroxytryptamine (5-HT)] system and plays an important role in the regulation of many physiological functions such as sleep/arousal, food intake and mood. In order to understand the reg... |
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The cyclooxygenase and nitric oxide synthesis/pathways mediate the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats.
Pharmacology 90(3-4) , 169-76, (2012) We investigated the mechanisms involved in the 5-hydroxytriptaminergic inhibitory action on the pressor responses elicited by sympathostimulation in long-term-diabetic pithed rats. Diabetes was induced in rats by alloxan administration. Eight weeks later, the... |
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5-HT(1A) receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia.
Pharmacol. Biochem. Behav. 103(2) , 367-72, (2012) Previously we reported that the 50% EtOH extract of Cinnamomum cassia (C. cassia) possesses anxiolytic-like activity in the mouse elevated plus maze (EPM) test. This activity was blocked by the 5-HT(1A) receptor antagonist, WAY 100635. Therefore, in order to ... |