沙利度胺结构式
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常用名 | 沙利度胺 | 英文名 | Thalidomide |
|---|---|---|---|---|
| CAS号 | 50-35-1 | 分子量 | 258.229 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 509.7±43.0 °C at 760 mmHg | |
| 分子式 | C13H10N2O4 | 熔点 | 269-271°C | |
| MSDS | 中文版 美版 | 闪点 | 262.1±28.2 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs.
Proc. Natl. Acad. Sci. U. S. A. 112(12) , E1471-9, (2015) Therapeutics developed and sold as racemates can exhibit a limited therapeutic index because of side effects resulting from the undesired enantiomer (distomer) and/or its metabolites, which at times, forces researchers to abandon valuable scaffolds. Therefore... |
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Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring.
Environ. Toxicol. 28(11) , 617-29, (2013) Pyrethroids are one of the most widely used classes of insecticides and show neurotoxic effects that induce oxidative stress in the neonatal rat brain. However, little is still known about effects of prenatal exposure to permethrin on vascular development in ... |
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Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase.
J. Chromatogr. A. 1358 , 208-16, (2014) A vancomycin-bonded silica monolithic column for capillary electrochromatography (CEC) was prepared by a single-step in situ sol-gel approach. This sol-gel process incorporates a synthetic sol-gel precursor which contains a macrocyclic antibiotic, vancomycin,... |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug Metab. Dispos. 36 , 1385-405, (2008) We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data. This data set provides the drug metabolism scientist ... |
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Lenalidomide for second-line treatment of advanced hepatocellular cancer: a Brown University oncology group phase II study.
Am. J. Clin. Oncol. 38(1) , 1-4, (2015) To assess the activity and toxicity of lenalidomide for patients with advanced hepatocellular cancer (HCC) previously treated with sorafenib.Patients with advanced HCC who progressed on or were intolerant to sorafenib were eligible. Patients received lenalido... |
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Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis.
PLoS ONE 10(2) , e0116961, (2015) Methamphetamine is a highly addictive psychostimulant that causes profound damage to the brain and other body organs. Post mortem studies of human tissues have linked the use of this drug to diseases associated with aging, such as coronary atherosclerosis and... |