对氨基苯甲酰胺结构式
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常用名 | 对氨基苯甲酰胺 | 英文名 | 4-Aminobenzamide |
|---|---|---|---|---|
| CAS号 | 2835-68-9 | 分子量 | 136.151 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 349.0±25.0 °C at 760 mmHg | |
| 分子式 | C7H8N2O | 熔点 | 181-183 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 164.9±23.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Cell death protection by 3-aminobenzamide and other poly(ADP-ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities.
Biochem. Biophys. Res. Commun. 199(2) , 525-30, (1994) The death of target cells by cytotoxic effector cells is a relevant biological phenomenon, where cells are activated and a very quick apoptotic program occurs. In order to test the hypothesis that the nuclear enzyme poly(ADP-ribose)polymerase (PADPRP) plays a... |
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Effect of inhibitors of poly(ADP-ribose)polymerase on the radiation response of HeLa S3 cells.
Radiat. Res. 119(2) , 380-6, (1989) The purpose of this study was to investigate possible involvement of poly(ADP-ribosyl)ation reactions in X-ray-induced cell killing, repair of potentially lethal damage (PLD), and formation and repair of radiation-induced DNA damage. As tools we used the inhi... |
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The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries.
J. Biochem. Biophys. Methods 43(1-3) , 87-111, (2000) A unique separator was developed which allowed automatic separation and peak collection using semi-preparative supercritical fluid chromatography (SFC). A peak detector switched the effluent between waste and special collection cassettes. Up to 50 mg of vario... |
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Effect of inhibitors of poly(ADP-ribose) polymerase on the heat response of HeLa S3 cells.
Radiat. Res. 116(3) , 406-15, (1988) The purpose of this study was to investigate a possible involvement of poly(ADP-ribosyl)ation reactions in hyperthermic cell killing and hyperthermic DNA strand-break induction and repair in HeLa S3 cells. The inhibitors of poly(ADP-ribose) polymerase, 3-amin... |
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Interferon-gamma inhibits insulin release and induces cell death in the pancreatic beta-cell line INS-1 independently of nitric oxide production.
Exp. Cell Res. 237(1) , 217-22, (1997) Interferon-gamma is among the cytokines which have been implicated as effector molecules of beta-cell destruction in autoimmune diabetes. Its mechanism of action is, however, largely unknown. In the present study rat pancreatic beta-cells, INS-1, were incubat... |
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Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.
Radiat. Res. 97(3) , 546-55, (1984) Postirradiation incubation of V79 Chinese hamster cells with inhibitors of poly(ADP-ribose) synthesis was found to potentiate the killing of cells by X rays. Potentiation increased with incubation time and with concentration of the inhibitor. Preirradiation i... |
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Ca(2+)-calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice.
Free Radic. Biol. Med. 31(3) , 277-91, (2001) Acetaminophen (AAP), the analgesic hepatotoxicant, is a powerful inducer of oxidative stress, DNA fragmentation, and apoptosis. The anti-apoptotic oncogene bcl-XL, and the pro-apoptotic oncogene p53 are two key regulators of cell cycle progression and/or apop... |
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Exosite interactions determine the affinity of factor X for the extrinsic Xase complex.
J. Biol. Chem. 275(37) , 28826-33, (2000) The initiation of coagulation results from the activation of factor X by an enzyme complex (Xase) composed of the trypsin-like serine proteinase, factor VIIa, bound to tissue factor (TF) on phospholipid membranes. We have investigated the basis for the protei... |
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Inhibition of nitric oxide induced cytotoxicity in pancreatic b-cells.
Biochem. Soc. Trans. 24(1) , 73S, (1996)
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Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation.
Mol. Cell Biochem. 218(1-2) , 27-33, (2001) Previous studies from our laboratories have linked the protective abilities of IH636 grape seed proanthocyanidin extract (GSPE) with inactivation of anti-apoptotic gene bcl-XL, and modification of several other critical molecular targets such as DNA-damage/DN... |