3-羟基-2-吡啶甲酸结构式
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常用名 | 3-羟基-2-吡啶甲酸 | 英文名 | 3-Hydroxypicolinic acid |
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CAS号 | 874-24-8 | 分子量 | 139.109 | |
密度 | 1.5±0.1 g/cm3 | 沸点 | 451.1±30.0 °C at 760 mmHg | |
分子式 | C6H5NO3 | 熔点 | 213-218 °C(lit.) | |
MSDS | 中文版 美版 | 闪点 | 226.6±24.6 °C | |
符号 |
GHS07 |
信号词 | Warning |
Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry.
Org. Biomol. Chem. 13(1) , 269-76, (2014) Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosphate bonds were assembled using commercially available nucl... |
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Electrochemiluminescent DNA sensor based on controlled Zn-mediated grafting of diazonium precursors.
Anal. Bioanal. Chem 407 , 5579-86, (2015) Controlled Zn-mediated grafting of a thin layer of a diazonium salt was used to functionalise a carbon electrode with ruthenium(II)-tris-bipyridine (Ru)-labelled DNA for use as a capture probe in an electrochemiluminescent genosensor. A secondary reporter pro... |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Ultraviolet/matrix-assisted laser desorption/ionization mass spectrometric characterization of 2,5-dihydroxybenzoic acid-induced reductive hydrogenation of oligonucleotides on cytosine residues.
J. Mass Spectrom. 35(8) , 1025-34, (2000) The changes in the ion signals in the isotope cluster, mass resolution, signal-to-noise ratio and mass accuracy for matrix-assisted laser desorption/ionization (MALDI) of DNA oligonucleotides (dGGATC, dCAGCt, and dAACCGTT) and their fragment ions were evaluat... |
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Spectrophotometric study of the complexation equilibria of iron(III) with 3-hydroxypicolinic acid and determination of iron in pharmaceutical preparations.
J. Chem. Technol. Biotechnol. 58(3) , 231-6, (1993) The complexation equilibria of iron(III) with 3-hydroxypicolinic acid (hypa) have been studied spectrophotometrically in 40% (v/v) ethanol-water medium at 25 degrees C and an ionic strength of 0.1 M NaClO4. The equilibria occurring in solution were establishe... |
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Antimycobacterial and antifungal isosters of salicylamides.
Arch. Pharm. (Weinheim) 336(6-7) , 322-35, (2003) A set of 40 derivatives of 3-hydroxypicolinic acid and 2-sulfanylbenzoic acid, isosteric to salicylanilides was synthesized. The compounds were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium,... |
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Ionization mechanism of oligonucleotides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid Commun. Mass Spectrom. 15(1) , 57-64, (2001) The ionization of nucleosides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was systematically investigated using adenine (A), thymine (T), guanine (G) and cytosine (C) with several common matrices. Experimental results of th... |
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A mixed matrix of 3-hydroxypicolinic acid and pyrazinecarboxylic acid for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of oligodeoxynucleotides.
Rapid Commun. Mass Spectrom. 18(7) , 787-94, (2004) A mixed matrix of 3-hydroxypicolinic acid (3-HPA) and pyrazinecarboxylic acid (PCA) was used for analysis of a variety of synthetic oligodeoxynucleotides ranging in length from 8-108-mers by matrix-assisted laser desorption/ionization time-of-flight mass spec... |
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A binary matrix for improved detection of phosphopeptides in matrix-assisted laser desorption/ionization mass spectrometry.
Rapid Commun. Mass Spectrom. 23(15) , 2264-72, (2009) Application of matrix-assisted laser-desorption/ionization mass spectrometry (MALDI MS) to analysis and characterization of phosphopeptides in peptide mixtures may have a limitation, because of the lower ionizing efficiency of phosphopeptides than nonphosphor... |
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Negative ion ultraviolet matrix-assisted laser desorption ionization mass spectrometry and post source decay of glycosyl esters of nucleoside pyrophosphates.
Eur. J. Mass Spectrom. (Chichester, Eng.) 14(6) , 401-9, (2008) Six different glycosyl esters of nucleoside pyrophosphates (monosaccharide nucleotides) were analyzed by means of matrix-assisted laser desorption/ionisation reflectron time-of-flight mass spectrometry (MALDI/RToF MS) in the negative ion mode. Several matrice... |