5-甲酰基尿嘧啶
5-甲酰基尿嘧啶结构式
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常用名 | 5-甲酰基尿嘧啶 | 英文名 | 5-Formyluracil |
|---|---|---|---|---|
| CAS号 | 1195-08-0 | 分子量 | 140.097 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C5H4N2O3 | 熔点 | >300 °C (dec.)(lit.) | |
| MSDS | 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Role of the Escherichia coli and human DNA glycosylases that remove 5-formyluracil from DNA in the prevention of mutations.
J. Radiat. Res. 42(1) , 11-9, (2001) Ionizing radiation induces a wide variety of modifications to purine and pyrimidine residues. The exocyclic methyl group of thymine does not escape oxidative damage. Any 5-hydroperoxymethyluracil produced is spontaneously decomposed to form 5-formyluracil (5-... |
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Repair of the mutagenic DNA oxidation product, 5-formyluracil.
DNA Repair (Amst.) 2(2) , 199-210, (2003) The oxidation of the thymine methyl group can generate 5-formyluracil (FoU). Template FoU residues are known to miscode, generating base substitution mutations. The repair of the FoU lesion is therefore important in minimizing mutations induced by DNA oxidati... |
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Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases.
Biochemistry 43(10) , 2682-7, (2004) 5-Formyluracil (fU) is a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation. Although this residue is a potentially mutagenic lesion and is removed by several base excision repair enzymes, it is unknown whether fU is the s... |
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Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
Biochemistry 42(17) , 5003-12, (2003) In the accompanying paper [Matsubara, M., et al. (2003) Biochemistry 42, 4993-5002], we have partially purified and characterized rat 5-formyluracil (fU)-DNA glycosylase (FDG). Several lines of evidence have indicated that FDG is a rat homologue of single-str... |
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Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cells.
Mutat. Res. 513(1-2) , 213-22, (2002) Oxidatively damaged thymine, 5-formyluracil (5-fU), was incorporated into a predetermined site of double-stranded shuttle vectors. The nucleotide sequences in which the modified base was incorporated were 5'-CFTAAG-3' and 5'-CTFAAG-3' (F represents 5-fU), the... |
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Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.
Nucleic Acids Res. 32(17) , 5291-302, (2004) Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-hydroxymethyluracil (hmU) and 5-formyluracil (fU) bearing an... |
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An unusual syn conformation of 5-formyluracil stabilized by supramolecular interactions.
Acta Crystallogr. C 63(Pt 11) , o650-4, (2007) The asymmetric unit of the amino-oxo tautomer of 5-formyluracil (systematic name: 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde), C(5)H(4)N(2)O(3), comprises one planar amino-oxo tautomer, as every atom in the structure lies on a crystallographic mirr... |
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Fragmentation of deprotonated ions of oligodeoxynucleotides carrying a 5-formyluracil or 2-aminoimidazolone.
J. Am. Soc. Mass Spectrom. 13(10) , 1190-4, (2002) 2-Aminoimidazolone and 5-formyluracil are major one-electron photooxidation products of guanine and thymine in oligodeoxynucleotides (ODNs). Herein we report the HPLC isolation and tandem mass spectrometric characterization of ODNs carrying those types of bas... |
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Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.
Radiat. Res. 161(4) , 442-50, (2004) HPLC analyses of condensed thymine irradiated with monochromatic synchrotron ultrasoft X rays in the energy region around nitrogen and oxygen K-shell edges were performed. Cobalt-60 gamma rays were used as a reference radiation. The radiation chemical dose re... |
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Structural and functional properties of CiNTH, an endonuclease III homologue of the ascidian Ciona intestinalis: critical role of N-terminal region.
Genes Genet. Syst. 87(2) , 115-24, (2012) Oxidatively damaged bases in DNA can cause cell death, mutation and/or cancer induction. To overcome such deleterious effects of DNA base oxidation, cells are equipped with base excision repair (BER) initiated by DNA glycosylases. Endonuclease III (Nth), a ma... |