十二烷基二甲基叔胺

J. Proteome Res. 14 , 2906-14, (2015)

We report a straightforward strategy to comprehensively monitor signal transduction pathway dynamics in mammalian systems. Combining targeted quantitative proteomics with highly selective phosphopeptide enrichment, we monitor, with great sensitivity, phosphor...

Small 10(24) , 5137-50, (2014)

The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of transcription (TAT) peptide-modified gold nanoparticle platform...

Biochem. Biophys. Res. Commun. 464 , 168-75, (2015)

Iron chelation is a promising therapeutic strategy for cancer that works, in part, by inducing overexpression of N-myc downstream-regulated gene 1 protein (NDRG1), a known growth inhibitor and metastasis suppressor. However, details of the signaling cascades ...

J. Pharm. Pharmacol. 67(3) , 450-63, (2015)

In this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis.The liposomal adjuvant composed of the cationic lipid dimethyldioctadecylammonium bromide (DDA)...

J. Am. Chem. Soc. 137(7) , 2495-505, (2015)

We investigate the relation between the chain length of ligands used and the size of the nanocrystals formed in the hot injection synthesis. With two different CdSe nanocrystal syntheses, we consistently find that longer chain carboxylic acids result in small...

J. Pharm. Biomed. Anal. 114 , 296-304, (2015)

Targeted immunocytokines (TICs) display potent activity in selective tumor suppression. This class of multi domain biotherapeutics (MDBs) is composed of the three major domains Fab, Fc, and a cytokine which may induce a complex polyclonal anti-drug antibody (...

Nanoscale Res. Lett. 10 , 144, (2015)

Nanosized rare earth (RE) hydroxides including La(OH)3, Nd(OH)3, Pr(OH)3, Sm(OH)3, Gd(OH)3, and Er(OH)3 with rod-like morphology are fabricated via a convenient hydrothermal approach. This strategy calls for the first preparation of metal complexes between RE...

J. Proteome Res. 14 , 3793-803, (2015)

We propose an efficient integration of SWATH with MRM for biomarker discovery and verification when the corresponding ion library is well established. We strictly controlled the false positive rate associated with SWATH MS signals and carefully selected the t...

Sci. Rep. 5 , 13430, (2015)

Upon infection, Mycobacterium tuberculosis (Mtb) deploys specialized secretion machinery to deliver virulent proteins with the capacity to modulate a variety of host-cellular pathways. Studies on the identification of intra-macrophage Mtb proteins, however, a...

J. Mol. Med. 93 , 645-62, (2015)

Proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) are related proteins exclusive to Mycobacteria that play diverse roles in modulating critical innate immune pathways. In this study, we observed that the PPE57 protein is associated with the c...