外消旋-顺-N-去甲基舍曲林盐酸盐
外消旋-顺-N-去甲基舍曲林盐酸盐结构式
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常用名 | 外消旋-顺-N-去甲基舍曲林盐酸盐 | 英文名 | rac-cis-N-Desmethyl Sertraline Hydrochloride |
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| CAS号 | 91797-57-8 | 分子量 | 328.66400 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C16H16Cl3N | 熔点 | 301-303ºC | |
| MSDS | N/A | 闪点 | 9 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.
J. Clin. Psychiatry 64(1) , 73-80, (2003) The purpose of this study was to attain a new landmark in the area of selective serotonin reuptake inhibitor therapy during lactation by establishing a basis for interpreting infant serum concentrations and for minimizing infant exposure in the absence of tre... |
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Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.
Am. J. Physiol. Heart Circ. Physiol. 285(6) , H2780-7, (2003) We recently reported the identification of a novel human adenosine A3 receptor-selective agonist, (2S,3S,4R,5R)-3-amino-5-[6-[5-chloro-2-(3-methylisoxazol-5-ylmethoxy)benzylamino]purin-9-yl]-4-hydroxytetrahydrofuran-2-carboxylic acid methylamide (CP-608,039),... |
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Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 221-9, (2009) A precise, sensitive and high throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of sertraline (SER) and its primary metabolite, N-desmethyl sertraline (NDS) in human plasma is developed and validated. T... |
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Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein.
Biol. Pharm. Bull. 31(2) , 231-4, (2008) The ATP-binding cassette (ABC) transporter protein subfamily B1 line (ABCB1) transporter P-glycoprotein (P-gp) plays an important role in the blood-brain barrier limiting a broad spectrum of substrates from entering the central nervous system. In the present ... |
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The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study.
Clin. Ther. 21(11) , 1890-9, (1999) Grapefruit juice is an inhibitor of cytochrome P-450 3A4 (CYP3A4). This study was designed to assess the in vitro and in vivo effects of grapefruit juice on sertraline metabolism. The in vitro assay involved analysis of sertraline metabolism by CYP3A4 using C... |
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Coadministration of short-term zolpidem with sertraline in healthy women.
J. Clin. Pharmacol. 39(2) , 184-91, (1999) This study was undertaken to determine whether there are pharmacokinetic (PK) interactions between zolpidem, a hypnotic, and sertraline, an antidepressant. Twenty-eight healthy female volunteers received a single dose of zolpidem alone and five consecutive do... |
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Conversion of sertraline to N-methyl sertraline in embalming fluid: a forensic implication.
J. Anal. Toxicol. 30(6) , 395-9, (2006) Zoloft (sertraline hydrochloride) is one of the antidepressant medications used to treat depression, obsessive-compulsive disorder, and social anxiety disorder. The practice of embalming a cadaver is common, yet it may create problems for forensic toxicologis... |
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Addition of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline.
Hum. Psychopharmacol. Clin. Exp. 23(8) , 707-13, (2008) In the present study, we examined the efficacy of risperidone addition on sertraline-resistant depressed patients and the effects of risperidone on the metabolism of sertraline. Ten patients (M/F: 4/6, age: 54 +/- 10 years) met the DSM-IV criteria for major d... |
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Partial compliance as determined from plasma levels of sertraline and its metabolite in depressed patients in primary care.
J. Clin. Psychopharmacol. 30(6) , 746-8, (2010)
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Human cytochromes mediating sertraline biotransformation: seeking attribution.
J. Clin. Psychopharmacol. 19(6) , 489-93, (1999)
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