L-谷氨酸二叔丁酯盐酸盐
L-谷氨酸二叔丁酯盐酸盐结构式
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常用名 | L-谷氨酸二叔丁酯盐酸盐 | 英文名 | H-Glu(OtBu)-OtBu.HCl |
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| CAS号 | 32677-01-3 | 分子量 | 295.803 | |
| 密度 | 1.02g/cm3 | 沸点 | 311.1ºC at 760 mmHg | |
| 分子式 | C13H26ClNO4 | 熔点 | 60 to 75ºC | |
| MSDS | 美版 | 闪点 | 78.1ºC |
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Synthesis and biological activity of analogues of the C-terminal hexapeptide of substance P with modifications at glutaminyl and methioninyl residues. Structure-activity studies.
Int. J. Pept. Protein Res. 40 , 395-400, (1992) Analogues of [Orn6]-SP6-11 have been synthesized in which the methionyl residue is replaced by glutamine gamma-carboxamide substituted derivatives. These analogues where tested in three in vitro preparations representative of NK-1, NK-2 and NK-3 receptor type... |
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Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.
Int. J. Pept. Protein Res. 41 , 411-414, (1993) Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. These analogues were tested in three in vitro preparations ... |
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Convulsant properties of L-glutamic acid di-tert butyl ester.
Neurobehav. Toxicol. Teratol. 7 , 275-278, (1985) Glutamic acid di-tert butyl ester (GTBE) was found to have a pronounced convulsant effect in mice and rats, producing recurrent clonic convulsions combined with postural and respiratory disturbances in a dosage of 0.5 mmol/kg (148 mg/kg). Tert-butyl ester der... |