偏二甲肼
一般危化品
偏二甲肼结构式
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常用名 | 偏二甲肼 | 英文名 | 1,1-Dimethylhydrazine |
|---|---|---|---|---|
| CAS号 | 57-14-7 | 分子量 | 60.098 | |
| 密度 | 0.8±0.1 g/cm3 | 沸点 | 63.9±9.0 °C at 760 mmHg | |
| 分子式 | C2H8N2 | 熔点 | -57.2 °C | |
| MSDS | 中文版 美版 | 闪点 | 1.1±0.0 °C | |
| 符号 |
GHS02, GHS05, GHS06, GHS08, GHS09 |
信号词 | Danger |
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Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models.
Biomaterials 51 , 161-72, (2015) As a synergistic drug combination, doxorubicin-loaded cisplatin crosslinked polysaccharide-based nanoparticles (Dex-SA-DOX-CDDP) have demonstrated enhanced antitumor efficacy and reduced systemic toxicity via optimized biodistribution, controlled drug release... |
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Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.
Oncol. Rep. 33(3) , 1131-40, (2015) Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed ... |
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Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach.
PLoS ONE 11 , e0151539, (2016) Doxycycline (DOX) exhibits anti-inflammatory, anti-tumor, and pro-apoptotic activity and is being tested in clinical trials as a chemotherapeutic agent for several cancers, including colon cancer.In the current study, the chemotherapeutic activity of doxycycl... |
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Micronucleus test and erythropoiesis: effect of cobalt on the induction of micronuclei by mutagens.
Environ. Mol. Mutagen. 22(2) , 101-6, (1993) The micronucleus test is used widely as an in vivo short-term assay for potential carcinogens. In the present study, results of the micronucleus test were affected by cobalt dichloride pretreatment. Cobalt dichloride was used to induce erythropoietin, a growt... |
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Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis.
Nutr. Cancer 64(4) , 559-68, (2012) Dietary factors play a significant role in colon cancer. The essential polyunsaturated fatty acids (PUFAs), n-3 PUFAs, and n-6 PUFAs exert inverse effect on cancer. This study was designed to understand the mechanism of chemopreventive action of different rat... |
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Determination of hydrazine, monomethylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine by nonaqueous capillary electrophoresis with amperometric detection.
Electrophoresis 26(17) , 3341-8, (2005) The present study is concerned with the application of nonaqueous capillary electrophoresis (NACE) with electrochemical detection (ED) to the separation and quantitative determination of hydrazine (Hy) and its methyl derivatives. The best performance of NACE-... |
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A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result of space activities.
Chemosphere 67(6) , 1108-16, (2007) A preliminary assessment of the potential environmental and human health impact of UDMH as a result of space activities has been carried out applying a theoretical approach in comparison with selected experimental data. The theoretical framework includes QSAR... |
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Organ-specific genotoxicity of the potent rodent colon carcinogen 1,2-dimethylhydrazine and three hydrazine derivatives: difference between intraperitoneal and oral administration.
Mutat. Res. 415(1-2) , 1-12, (1998) We used a modification of the alkaline single cell gel electrophoresis (SCG) (Comet) assay to test the in vivo genotoxicity of four hydrazine derivatives--1,2-dimethylhydrazine (SDMH), 1,1-dimethylhydrazine (UDMH), hydrazine (HZ), and procarbazine (PCZ)--in m... |
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Effects of prostaglandin E2 on the micronucleus formation in mouse bone marrow cells by various mutagens.
Mutat. Res. 311(2) , 287-93, (1994) The effects of prostaglandin E2 (PGE2), as a trigger of erythroid progenitor cells into the cell cycle, were studied on the induction of micronuclei by various mutagens; with mitomicin C (MMC) the optimal protocol was established. PGE2 itself did not induce a... |
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Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1-dimethylhydrazine, in a medium-term bioassay.
Teratog. Carcinog. Mutagen. 15(6) , 307-12, (1995) The carcinogenicity of daminozide (succinic acid-2,2-dimethylhydrazide; Alar), a plant growth regulator used primarily in apple orchards, has been the subject of recent investigations by several national and international organizations because of contradictor... |