6-乙基-5,6,7,8-四氢-4H-噁唑并[4,5-d]氮杂-2-胺二盐酸盐
![6-乙基-5,6,7,8-四氢-4H-噁唑并[4,5-d]氮杂-2-胺二盐酸盐结构式](https://image.chemsrc.com/caspic/077/36067-72-8.png)
6-乙基-5,6,7,8-四氢-4H-噁唑并[4,5-d]氮杂-2-胺二盐酸盐结构式
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常用名 | 6-乙基-5,6,7,8-四氢-4H-噁唑并[4,5-d]氮杂-2-胺二盐酸盐 | 英文名 | Azepexole dihydrochloride |
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| CAS号 | 36067-72-8 | 分子量 | 254.16 | |
| 密度 | 1.126g/cm3 | 沸点 | 330.9ºC at 760mmHg | |
| 分子式 | C9H17Cl2N3O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 153.9ºC |
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The role of several alpha(1)- and alpha(2)-adrenoceptor subtypes mediating vasoconstriction in the canine external carotid circulation.
Br. J. Pharmacol. 132 , 1292-1298, (2001) 1. It has recently been shown that both alpha(1)- and alpha(2)-adrenoceptors mediate vasoconstriction in the canine external carotid circulation. The present study set out to identify the specific subtypes (alpha(1A), alpha(1B) and alpha(1D) as well as alpha(... |
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Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats.
Eur. J. Pharmacol. 554(2-3) , 205-11, (2007) It has been suggested that the alpha(2)-adrenoceptors mediating cardiac sympatho-inhibition in pithed rats closely resemble the pharmacological profile of the alpha(2A)-adrenoceptor subtype. However, several lines of evidence suggest that more than one subtyp... |
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Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats.
Auton. Neurosci. 143(1-2) , 40-5, (2008) Imidazoline derivatives (e.g. clonidine and moxonidine) and alpha(2)-adrenoceptor agonists (e.g. B-HT 933) have been shown to inhibit sympathetically-induced [(3)H]noradrenaline release in several isolated blood vessels. The present study has compared the pot... |
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Inhibition of placental 11beta-hydroxysteroid dehydrogenase type 2 by catecholamines via alpha-adrenergic signaling.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 281(6) , R1966-74, (2001) The placenta expresses high levels of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) that converts cortisol into inactive 11-keto metabolites and effectively protects the developing fetus from maternal cortisol during pregnancy. Impairment of this gl... |
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Characterization of postjunctional alpha-adrenoceptors in the pithed mouse.
Gen. Pharmacol. 33(1) , 99-105, (1999) The adrenoceptor subtypes responsible for the pressor response to alpha1- and alpha2-adrenoceptor agonists have not yet been established, although gene knockout experiments in the mouse have provided evidence for a role of the alpha1B- and alpha2B-adrenocepto... |
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Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction.
Pharmacogenetics 13(5) , 279-84, (2003) The 825T allele of a polymorphism at GNB3, encoding the G protein beta(3) subunit, is associated with an enhanced coronary blood flow (CBF) reduction in response to alpha(2)-, but not to alpha(1)-adrenoceptor activation. Because the regulation of vascular ton... |
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Postjunctional alpha 2-adrenoceptors are not present in proximal arterioles of rat intestine.
Am. J. Physiol. 274(1 Pt 2) , H202-8, (1998) The purpose of this study was to evaluate two potential stimuli for nitric oxide (NO) release in rat intestinal arterioles during sympathetic nerve activation. To determine whether these vessels contain endothelial alpha 2-adrenoceptors linked to the L-argini... |
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Alpha1- and alpha2-adrenoceptor control of sodium transport reverses in developing hypertension.
Hypertension 33(1 Pt 2) , 524-9, (1999) Alpha-Adrenergic receptor (AR) activation enhances sodium retention in certain forms of hypertension. The objective of the present study was to understand the role of alpha-ARs in regulating sodium transport by distal tubules (DT). DT cells were isolated from... |
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Pharmacological identification of the α₂-adrenoceptor subtypes mediating the vasopressor responses to B-HT 933 in pithed rats.
Eur. J. Pharmacol. 691(1-3) , 118-24, (2012) It has been shown that α(2)-adrenoceptors mediate vasopressor responses in pithed rats. However, the corresponding α(2)-adrenoceptor subtypes have not been pharmacologically identified. Thus, this study set out to identify the specific subtypes (α(2A), α(2B) ... |
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Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome.
Microcirculation 13(7) , 587-95, (2006) This study tested whether alpha -adrenoceptor-mediated coronary vasoconstriction is augmented in the metabolic syndrome and is accompanied by the alteration of specific alpha(1)- and alpha(2)-coronary adrenoceptors.Studies were conducted in control and chroni... |