牛蒡子苷
牛蒡子苷结构式
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常用名 | 牛蒡子苷 | 英文名 | Arctiin |
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| CAS号 | 20362-31-6 | 分子量 | 534.552 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 756.4±60.0 °C at 760 mmHg | |
| 分子式 | C27H34O11 | 熔点 | 109 °C | |
| MSDS | 中文版 美版 | 闪点 | 250.1±26.4 °C |
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Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.
Planta Med. 78(8) , 800-6, (2012) The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of t... |
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Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
Fitoterapia 86 , 6-12, (2013) Arctiin, an important lignan compound in Fructus Arctii, has been reported to possess various kinds of bioactivities. Previous studies on the pharmacokinetic of arctiin after oral administration showed that it had a rapid absorption phase followed by a sharp ... |
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Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats.
Planta Med. 78(12) , 1317-23, (2012) Diabetic retinopathy is one of the most common and severe complications of diabetes mellitus. Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L., has been reported to have antidiabetic activity. In this study, we investigated the ef... |
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Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
Biol. Pharm. Bull. 33(7) , 1199-205, (2010) Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses,... |
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Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Planta Med. 77(13) , 1525-7, (2011) The seeds of Arctium lappa L. (AL, family Asteraceae), the main constituents of which are arctiin and arctigenin, have been used as an herbal medicine or functional food to treat inflammatory diseases. These main constituents were shown to inhibit acetylcholi... |
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Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats.
Phytother Res. 27(10) , 1474-80, (2013) Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permeability of glomerular basement membrane plays an important role in DN pathogenesis. This study was performed to assess the effect of arctiin, the lignan constituen... |
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Optimum yields of dibenzylbutyrolactone-type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods.
Phytochem. Anal. 23(6) , 598-603, (2012) Dibenzylbutyrolactone-type lignans are the physiologically active constituents of the achene fruits of Cynareae. These lignans occur in glycoside/aglycone forms: in the highest quantity of the arctiin/arctigenin, matairesinoside/matairesinol and tracheloside/... |
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Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats.
Cancer Lett. 222(2) , 145-51, (2005) Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. Modifyi... |
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Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 860(1) , 127-33, (2007) A microemulsion electrokinetic chromatography method was used to separate arctiin and arctigenin in Fructus Arctii and its herbal preparations. The separation of arctiin and arctigenin was performed using a 1-butanol-SDS-ethyl acetate-water microemulsion in 1... |
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Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.
Oncol. Rep. 19(3) , 721-7, (2008) Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties in animal models. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. However, the growth inhibitory mechanism of arctiin re... |