那格列奈

Pak. J. Pharm. Sci. 26(6) , 1229-35, (2013)

This study involves the design and characterization of Nateglinide (NAT) microspheres to enhance patient compliance. Ionic gelation technique was used to prepare Nateglinide Microspheres by using rate controlling polymers Carbopol-940 and Hydroxypropylmethyl ...

Health Policy 104(1) , 27-31, (2012)

In Germany, coverage decisions in the statutory health insurance (SHI) system are based on the principles of evidence-based medicine. Recently, an evidence assessment by the Institute for Quality and Efficiency in Health Care (IQWiG) of the oral antidiabetics...

Int. J. Clin. Pract. 59(10) , 1218-28, (2005)

Therapy for type 2 diabetes mellitus should aim to control not only fasting, but also postprandial glucose levels. Nateglinide, a d-phenylalanine derivative, restores postprandial early phase insulin secretion in a transient and glucose-sensitive manner witho...

Diabetes Obes. Metab. 14(2) , 187-9, (2012)

This study was performed to examine the efficacy and safety of mitiglinide in type 2 diabetes patients (T2DM). Enrolled patients had received treatment with diet and exercise in the previous 3 months with glycosylated haemoglobin (HbA1c) 7-10%, and were rando...

Int. J. Clin. Pract. 57(6) , 535-41, (2003)

Nateglinide is a new oral antidiabetic agent that stimulates insulin release promptly after its pre-meal administration in a strongly glucose-dependent fashion. Because its insulinotropic effects are short in duration, nateglinide specifically targets postpra...

Int. J. Pharm. 454(1) , 568-72, (2013)

Nateglinide is an oral antidiabetic agent that should be administered 10-30 min before the meal, but it shows low and pH-dependent solubility that may reduce its oral bioavailability. To improve nateglinide dissolution rate, the active was co-milled with thre...

Int. J. Pharm. 454(1) , 562-7, (2013)

Nateglinide is a non-sulphonylurea insulinotropic oral antidiabetic agent. The main problem in formulating an oral dosage form is its low solubility in aqueous media. This problem is particularly critical for an anti-diabetic drug because it should be adminis...

J. Pharm. Sci. 101(5) , 1843-51, (2012)

Relationship between two polymorphs is described to be either enantiotropic or monotropic with transition temperature/transition point (T(t) ) below the melting point (T(m) ) of the lower melting form in former case and above the T(m) of the higher melting fo...

Curr. Drug Deliv. 9(6) , 628-36, (2012)

In current research, chitosan was reacted with mono-chloroacetic acid under alkaline condition to prepare carboxymethyl chitosan (CMCTs). The degree of substitution (Ds) on prepared CMCTs was found to be 0.68. CMCTs was used as a potential carrier for pH spec...

Ann. Pharmacother. 35(11) , 1426-34, (2001)

To review the pharmacology, pharmacokinetics, dosing guidelines, adverse effects, drug interactions, and clinical efficacy of nateglinide.Primary and review articles regarding nateglinide were identified by MEDLINE search (from 1966 to January 2001); abstract...