6-氨基尿嘧啶
6-氨基尿嘧啶结构式
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常用名 | 6-氨基尿嘧啶 | 英文名 | 6-Aminouracil |
|---|---|---|---|---|
| CAS号 | 873-83-6 | 分子量 | 127.101 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | 580.4±53.0 °C at 760 mmHg | |
| 分子式 | C4H5N3O2 | 熔点 | ≥360 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 304.8±30.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.
Mini Rev. Med. Chem. 5(12) , 1113-23, (2005) Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anti... |
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Synthesis of 6-aminouracils and pyrrolo[2,3-d]pyrimidine-2,4-diones and their inhibitory effect on thymidine phosphorylase.
Nucleic Acids Symp. Ser. (37) , 59-60, (1997) Inhibitors of thymidine phosphorylase (dThdPase) are expected to suppress the growth and metastasis of tumor cells by inhibition of angiogenesis and were designed by utilizing the three dimensional structure of the enzyme. 5-Substituted 6-aminouracils (5) and... |
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Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.
Acta Pol. Pharm. 53(1) , 39-46, (1996) Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is described. Compounds III, V, VI in the Mannich reaction with sec... |
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Cocrystals of 5-fluorocytosine. I. Coformers with fixed hydrogen-bonding sites.
Acta Crystallogr. B 68(Pt 4) , 431-43, (2012) The antifungal drug 5-fluorocytosine (4-amino-5-fluoro-1,2-dihydropyrimidin-2-one) was cocrystallized with five complementary compounds in order to better understand its drug-receptor interaction. The first two compounds, 2-aminopyrimidine (2-amino-1,3-diazin... |
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6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3.
J. Med. Chem. 42(11) , 2035-40, (1999) 6-Anilinouracils (6-AUs) are dGTP analogues which selectively inhibit the DNA polymerase III of Bacillus subtilis and other Gram-positive bacteria. To enhance the potential of the 6-AUs as antimicrobial agents, a structure-activity relationship was developed ... |
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Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(1-2) , 65-70, (2009) Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. UA can react directly with nitric oxide to generate 6-aminouracil and with peroxynitrite to yield triuret; both of the... |
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Effect of amino substitution on the excited state dynamics of uracil.
Photochem. Photobiol. Sci. 7(7) , 765-8, (2008) The excited state deactivation of two amino-substituted uracils, 5-aminouracil (5AU) and 6-aminouracil (6AU) in aqueous solution was studied by femtosecond fluorescence upconversion. The fluorescence of 6AU decays as fast as that of uracil with a unique time ... |
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The peculiar spectral properties of amino-substituted uracils: a combined theoretical and experimental study.
J. Phys. Chem. B 114(39) , 12708-19, (2010) A detailed experimental and computational study of the absorption and fluorescence spectra of 5-aminouracil (5 AU) and 6-aminouracil (6 AU) in aqueous solution is reported. The lowest energy band of the steady-state absorption spectra of 5 AU is considerably ... |
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Inhibition of uracil-DNA glycosylase increases SCEs in BrdU-treated and visible light-irradiated cells.
Exp. Cell Res. 161(1) , 172-80, (1985) We have approached the study of the ability of different types of lesions produced by DNA-damaging agents to develop sister-chromatid exchanges (SCEs) by analyzing SCE levels observed in Allium cepa L cells with BrdU-substituted DNA and exposed to visible lig... |
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Inactivation of nitric oxide by uric acid.
Nucleosides Nucleotides Nucleic Acids 27(8) , 967-78, (2008) The 1980 identification of nitric oxide (NO) as an endothelial cell-derived relaxing factor resulted in an unprecedented biomedical research of NO and established NO as one of the most important cardiovascular, nervous and immune system regulatory molecule. A... |