氟哌啶醇结构式
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常用名 | 氟哌啶醇 | 英文名 | haloperidol |
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CAS号 | 52-86-8 | 分子量 | 375.864 | |
密度 | 1.2±0.1 g/cm3 | 沸点 | 529.0±50.0 °C at 760 mmHg | |
分子式 | C21H23ClFNO2 | 熔点 | 152 °C | |
MSDS | 中文版 美版 | 闪点 | 273.8±30.1 °C | |
符号 |
GHS06, GHS08 |
信号词 | Danger |
Revival of physostigmine - a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients.
Clin. Chem. Lab Med. 53 , 1259-64, (2015) Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physosti... |
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Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels.
Nat. Commun. 4 , 1435, (2013) The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for motor coordination. Here we describe a novel mechanism by which... |
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Identification and quantification of 35 psychotropic drugs and metabolites in hair by LC-MS/MS: application in forensic toxicology.
Int. J. Legal Med. 129(2) , 259-68, (2015) Despite a non-invasive sampling, hair samples are generally collected in limited amounts for an obvious esthetic reason. In order to reduce the required quantity of samples, a multianalytes method allowing simultaneous identification and quantification of 35 ... |
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The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.
PLoS Med. 12(2) , e1001782, (2015) We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders. For example, halope... |
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Salt effects in electromembrane extraction.
J. Chromatogr. A. 1347 , 1-7, (2014) Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs ... |
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The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.
AAPS J. 16(6) , 1247-58, (2014) Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kid... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Applying 'Sequential Windowed Acquisition of All Theoretical Fragment Ion Mass Spectra' (SWATH) for systematic toxicological analysis with liquid chromatography-high-resolution tandem mass spectrometry.
Anal. Bioanal. Chem 407(2) , 405-14, (2015) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become an indispensable analytical technique in clinical and forensic toxicology for detection and identification of potentially toxic or harmful compounds. Particularly, non-target LC-MS/MS assays... |
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Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Behav. Brain Res. 278 , 186-92, (2015) Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel therapeutic a... |
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Neurotransmitter-mediated anxiogenic action of PACAP-38 in rats.
Behav. Brain Res. 281 , 333-8, (2015) The action of PACAP-38 was studied by measuring the anxiogenic-anxiolytic behavior of rats in an elevated plus maze. PACAP-38 was administered into the lateral brain ventricle and the behavior of the animals was measured 3h later. The possible involvement of ... |