Z-谷氨酰甘氨酸
Z-谷氨酰甘氨酸结构式
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常用名 | Z-谷氨酰甘氨酸 | 英文名 | Z-Gln-Gly-OH |
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| CAS号 | 6610-42-0 | 分子量 | 337.32800 | |
| 密度 | 1.339g/cm3 | 沸点 | 748ºC at 760 mmHg | |
| 分子式 | C15H19N3O6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 406.2ºC |
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A direct continuous spectrophotometric assay for transglutaminase activity.
Anal. Biochem. 285 , 16-20, (2000) Herein we report the development of a direct and continuous spectrophotometric method for determining transglutaminase (TGase) activity by using N,N-dimethyl-1,4-phenylenediamine (DMPDA) as a gamma-glutamyl acceptor substrate and carbobenzyloxy-l-glutamylglyc... |
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Chemoenzymatic synthesis of neoglycopeptides: application to an alpha-Gal-terminated neoglycopeptide.
J. Org. Chem. 66 , 2948-56, (2001) A novel methodology for the enzymatic preparation from suitably derivatized oligosaccharides of N-linked neoglycopeptides using the microbial glutaminyl-peptide gamma-glutamyl transferase, transglutaminase (TGase), is described. N-Allyl glycosides of various ... |
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Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates.
Biochemistry 42 , 9466-9481, (2003) Tissue transglutaminase (TGase) catalyzes transfer of gamma-acyl moieties of Gln residues in peptides or protein substrates to either water or amine nucleophiles through an acyl-enzyme intermediate formed from initial acyl-transfer to an active site Cys resid... |
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Transglutaminase-mediated synthesis of a DNA-(enzyme)n probe for highly sensitive DNA detection.
Chemistry 17 , 5387-5392, (2011) A new synthetic strategy for DNA-enzyme conjugates with a novel architecture was explored using a natural cross-linking catalyst, microbial transglutaminase (MTG). A glutamine-donor substrate peptide of MTG was introduced at the 5-position on the pyrimidine o... |
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Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility.
J. Pharm. Sci. 98 , 4420-4428, (2009) Polymer-drug and polymer-protein conjugates are promising candidates for the delivery of therapeutic agents. PEGylation, using poly(ethylene glycol) for the conjugation, is now the gold standard in this field, and some PEGylated proteins have successfully rea... |
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Functional glass surface displaying a glutamyl donor substrate for transglutaminase-mediated protein immobilization.
Biotechnol. J. 5 , 456-462, (2010) A chemically modified glass surface displaying a glutamyl donor substrate peptide (Z-QG) was developed for microbial transglutaminase (MTG)-mediated immobilization of recombinant proteins tagged with an MTG-reactive lysine-containing substrate peptide (K-tag)... |
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New fluorescent substrates of microbial transglutaminase and its application to peptide tag-directed covalent protein labeling.
Methods Mol. Biol. 751 , 81-94, (2011) Transglutaminase (TGase) is an enzyme that catalyzes the post-translational covalent cross-linking of Gln- and Lys-containing peptides and/or proteins according to its substrate specificity. We have recently designed a variety of Gln-donor fluorescent substra... |
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Enzymatically catalyzed conjugation of a biodegradable polymer to proteins and small molecules using microbial transglutaminase.
Methods Mol. Biol. 751 , 17-27, (2011) Hydroxyethyl starch (HES) is a water-soluble, biodegradable derivative of starch that is widely used in biomedicine as a plasma volume expander. Due to its favorable properties, HES is currently being investigated at the industrial and academic levels as a bi... |